怀孕期间使用设备测量的静止时间和身体活动与心脏自主调节的等时关联。
Isotemporal Associations of Device-Measured Sedentary Time and Physical Activity with Cardiac-Autonomic Regulation in Previously Pregnant Women.
机构信息
Department of Exercise Physiology, College of Sport Sciences and Physical Activity, King Saud University, King Khalid Rd, B69-G1 Building, Riyadh, 80200, Saudi Arabia.
Department of Health and Human Development, School of Education, University of Pittsburgh, 140 Trees Hall, Pittsburgh, PA, 15261, USA.
出版信息
Int J Behav Med. 2023 Aug;30(4):497-508. doi: 10.1007/s12529-022-10113-6. Epub 2022 Jul 11.
BACKGROUND
High sedentary time (ST) and low physical activity may increase cardiovascular risk, potentially though cardiac-autonomic dysregulation. This study investigated associations of statistically exchanging device-measured ST and physical activity with measures of cardiac-autonomic regulation in previously pregnant women.
METHOD
This cross-sectional, secondary analysis included 286 women (age = 32.6 ± 5.7 years; 68% white) measured 7-15 years after delivery. ST and light (LPA), moderate (MPA), vigorous (VPA), and moderate-to-vigorous (MVPA) intensity physical activity were measured by ActiGraph GT3X. ST was further partitioned into long (≥ 30 min) and short (< 30 min) bouts. MVPA was also partitioned into long (≥ 10 min) and short (< 10 min) bouts. Cardiac-autonomic regulation was assessed by heart rate variability (HRV) (resting heart rate, natural log transformed standard deviation of normal R-R intervals [lnSDNN], natural log-transformed root mean square of successive differences [lnRMSSD]) from a 5-min seated ECG. Progressive isotemporal substitution models adjusted for confounders. Sensitivity analyses removed women with related underlying medical conditions and who did not meet respiration rate criteria.
RESULTS
Initial analyses found no significant associations with HRV when exchanging 30 min of ST and physical activity (p > 0.05). Yet, replacing long- and short-bout ST with 30 min of long-bout MVPA yielded significantly higher (healthier) lnRMSSD (B = 0.063 ± 0.030 and B = 0.056 ± 0.027, respectively; both p < 0.05). Sensitivity analyses strengthened these associations and yielded further associations of higher lnSDNN and lnRMSSD when replacing 30 min of short-bout MVPA with equivalent amounts of long-bout MVPA (B = 0.074 ± 0.037 and B = 0.091 ± 0.046, respectively).
CONCLUSION
Replacing ST with long-bout MVPA is a potential strategy to improve cardiac-autonomic function in previously pregnant women.
背景
高静坐时间（ST）和低体力活动可能会增加心血管风险，潜在机制可能是心脏自主神经调节失调。本研究旨在调查在产后 7-15 年的女性中，用设备测量的 ST 和体力活动的统计学交换与心脏自主调节测量值之间的关联。
方法
这是一项横断面、二次分析研究，共纳入 286 名女性（年龄=32.6±5.7 岁；68%为白人）。ST 和轻（LPA）、中（MPA）、剧烈（VPA）和中高强度（MVPA）体力活动通过 ActiGraph GT3X 进行测量。ST 进一步分为长（≥30 分钟）和短（<30 分钟）段。MVPA 也分为长（≥10 分钟）和短（<10 分钟）段。通过 5 分钟静息心电图评估心率变异性（HRV）（静息心率、自然对数转换的正常 R-R 间隔标准差[lnSDNN]、自然对数转换的连续差值均方根[lnRMSSD]）来评估心脏自主调节。采用协变量调整的渐进等时替代模型。敏感性分析排除了患有相关基础疾病且不符合呼吸频率标准的女性。
结果
初步分析发现，用 30 分钟的 ST 和体力活动替代 30 分钟的 ST 与 HRV 无显著相关性（p>0.05）。然而，用 30 分钟的长段 MVPA 替代长段和短段 ST，可显著提高 lnRMSSD（B=0.063±0.030 和 B=0.056±0.027，均 p<0.05）。敏感性分析加强了这些关联，并进一步发现用 30 分钟短段 MVPA 替代同等长段 MVPA 时，lnSDNN 和 lnRMSSD 也显著升高（B=0.074±0.037 和 B=0.091±0.046，均 p<0.05）。
结论
用长段 MVPA 替代 ST 可能是改善产后女性心脏自主神经功能的一种潜在策略。
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