Alkan Gülsüm, Emiroğlu Melike, Tüter Öz Sadiye Kübra, Emiroğlu Halil Haldun, Türk Dağı Hatice, Körez Muslu Kazım
Department of Pediatrics, Division of Pediatric Infectious Diseases, Selçuk University, Faculty of Medicine, Konya, Turkey.
Department of Pediatrics, Division of Pediatric Gastroenterology, Selçuk University, Faculty of Medicine, Konya, Turkey.
Turk Arch Pediatr. 2022 Jul;57(4):413-420. doi: 10.5152/TurkArchPediatr.2022.22011.
Coronavirus disease 2019 is a major health problem in all age groups. Although most clinical symptoms are respiratory, gastrointestinal symptoms are often reported. This is a major concern for children and has limited research coverage. In this study, we evaluated the frequencies of gastrointestinal symptoms and liver biochemical findings in children with coronavirus disease 2019 and their relationship with clinical course and length of hospital stay.
Demographic data, clinical, and laboratory findings of children with Coronavirus disease 2019 who were followed up by the Department of Pediatric Infectious Diseases between March 2020 and August 2020 were recorded. They were classified accord- ing to age groups as <5 years, 5-10 years, and >10 years. Laboratory findings were analyzed according to age groups. Demographic, clinical, and laboratory findings were compared in both situations, the presence of gastrointestinal symptoms and the presence of elevated liver enzymes. It was considered statistically significant if it was <.05.
A total of 294 patients (median age 10 years [14 days to 18 years]) were enrolled in this study. Although fever is the most common symptom of coronavirus disease 2019, 15.6% of patients presented with acute gastroenteritis. Most patients with liver involvement (n = 130, 44.2%) were under 5 years of age (n = 74, 56.9%, P <.001). The patterns of abnormal liver test results were cholestatic (71.5%), hepatocellular (18.4%), and mixed (10%) types. Severe or mas- sive elevation of aminotransferase or liver failure was not observed. No statistically significant difference was noted in outcomes, including length of stay, for patients with gastrointestinal symptoms (P = .178) or liver involvement (P = .146).
The presence of gastrointestinal symptoms or elevated liver enzymes does not affect the course of the disease in children with coronavirus disease 2019.
2019冠状病毒病是所有年龄组的一个主要健康问题。尽管大多数临床症状是呼吸道症状，但胃肠道症状也经常被报道。这是儿童的一个主要关注点，且研究覆盖有限。在本研究中，我们评估了2019冠状病毒病患儿胃肠道症状和肝脏生化检查结果的发生率及其与临床病程和住院时间的关系。
记录了2020年3月至2020年8月期间由儿科传染病科随访的2019冠状病毒病患儿的人口统计学数据、临床和实验室检查结果。他们按年龄组分为<5岁、5 - 10岁和>10岁。实验室检查结果按年龄组进行分析。比较了出现胃肠道症状和出现肝酶升高这两种情况下的人口统计学、临床和实验室检查结果。如果P值<.05，则认为具有统计学意义。
本研究共纳入294例患者（中位年龄10岁[14天至18岁]）。尽管发热是2019冠状病毒病最常见的症状，但15.6%的患者出现急性胃肠炎。大多数肝脏受累患者（n = 130，44.2%）年龄在5岁以下（n = 74，56.9%，P <.001）。肝酶检查结果异常的模式为胆汁淤积型（71.5%）、肝细胞型（18.4%）和混合型（10%）。未观察到转氨酶严重或大量升高或肝衰竭。有胃肠道症状的患者（P = .178）或肝脏受累的患者（P = .146）在包括住院时间在内的结局方面未观察到统计学显著差异。
胃肠道症状或肝酶升高的存在并不影响2019冠状病毒病患儿的病程。
