Berghem L, Hansson M, Lundborg M, Camner P
Environ Res. 1987 Jun;43(1):179-85. doi: 10.1016/s0013-9351(87)80069-5.
Groups of rabbits were exposed by inhalation to chlorides of cobalt, nickel, and manganese as well as to tri- and hexavalent chromium at metal concentrations ranging from 0.4 to 3.9 mg/m3 for 1-4 months (5 days/week, 6 hr/day). Fibronectin content and lysozyme (muramidase) activity in lavage fluid were measured after all treatments and in alveolar macrophages after treatment with nickel chloride. In the lavage fluid no marked changes were seen in fibronectin content and lysozyme activity after exposure to tri- or hexavalent chromium or manganese. Nickel exposure significantly decreased the lysozyme activity in the lavage fluid and in the macrophages whereas the fibronectin content was unchanged in the lavage fluid and significantly increased in the macrophages. Both fibronectin content and lysozyme activity were increased markedly in the lavage fluid after cobalt exposure.
将兔分组，通过吸入方式使其暴露于钴、镍、锰的氯化物以及三价和六价铬中，金属浓度范围为0.4至3.9毫克/立方米，暴露时间为1至4个月（每周5天，每天6小时）。在所有处理后测量灌洗液中的纤连蛋白含量和溶菌酶（胞壁质酶）活性，并在氯化镍处理后测量肺泡巨噬细胞中的纤连蛋白含量和溶菌酶活性。暴露于三价或六价铬或锰后，灌洗液中的纤连蛋白含量和溶菌酶活性未见明显变化。镍暴露显著降低了灌洗液和巨噬细胞中的溶菌酶活性，而灌洗液中的纤连蛋白含量未变，巨噬细胞中的纤连蛋白含量显著增加。钴暴露后，灌洗液中的纤连蛋白含量和溶菌酶活性均显著增加。
