Manta P, Vassilopoulos D, Spengos M
Eur Arch Psychiatry Neurol Sci. 1987;236(4):235-6. doi: 10.1007/BF00383854.
In order to investigate possible changes in the nucleo-cytoplasmic ratio of the muscle fibres during ageing, samples of quadriceps femoris from 15 normal individuals whose age ranged from 17 to 82 years were studied (autopsy material). The mean lesser diameter and the number and size of the muscle fibre nuclei were calculated using a planimetric technique. It was found that nucleo-cytoplasmic ratio increased significantly after the age of 60 years. This was due to a decrease in the mean fibre size whilst the number and the size of myonuclei remained unchanged. The resemblance of this finding to denervation atrophy changes is noted.
为了研究衰老过程中肌纤维核质比的可能变化，对15名年龄在17至82岁之间的正常个体（尸检材料）的股四头肌样本进行了研究。使用平面测量技术计算了肌纤维核的平均较小直径以及数量和大小。结果发现，60岁以后核质比显著增加。这是由于平均纤维大小减小，而肌核的数量和大小保持不变。注意到这一发现与去神经萎缩变化的相似性。
