应用英夫利昔单抗治疗难治性蚕蚀性角膜溃疡完全成功。
The Complete Success in Refractory Mooren's Ulcer Treated with Infliximab.
机构信息
Department of Ophthalmology, Hatay Mustafa Kemal University Tayfur Ata Sokmen Medical School, Hatay, Turkey.
Department of Ophthalmology, Bayındır Hospital, Ankara, Turkey.
出版信息
Ocul Immunol Inflamm. 2023 May;31(4):682-688. doi: 10.1080/09273948.2022.2091615. Epub 2022 Jul 13.
PURPOSE
To describe the management and outcome of two extremely rare and painful cases of Mooren's ulcer, an idiopathic peripheral autoimmune-associated ulcerative corneal disease.
METHODS
Case report with literature review on the management of ocular inflammation in Mooren's ulcer.
RESULTS
A 47-year-old female and a 76-year-old female presented with progressive bilateral Mooren's ulcer that were refractory to conventional immunosuppressive therapy. Following treatment with infliximab, an anti-tumor necrosis factor alpha, a significant improvement in disease progression was observed, with no corneal thinning or perforation at follow-ups.
CONCLUSION
This case report highlights how infliximab can be effective in cases with Mooren's ulcer refractory to conventional therapies.
目的
描述两例极其罕见且痛苦的莫伦溃疡（一种特发性周围自身免疫相关溃疡性角膜疾病）的治疗方法和结果。
方法
对莫伦溃疡的眼部炎症管理进行病例报告并结合文献复习。
结果
一名 47 岁女性和一名 76 岁女性均出现双侧进行性莫伦溃疡，对常规免疫抑制治疗无反应。使用抗肿瘤坏死因子-α的英夫利昔单抗治疗后，疾病进展显著改善，随访时无角膜变薄或穿孔。
结论
本病例报告强调了英夫利昔单抗在常规治疗无效的莫伦溃疡病例中的有效性。
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