Stonnington C M, Phillips S F, Melton L J, Zinsmeister A R
Gut. 1987 Apr;28(4):402-9. doi: 10.1136/gut.28.4.402.
Utilising the population based data resources of the Rochester Epidemiology Project, we determined the incidence and prevalence of chronic ulcerative colitis among Rochester, Minnesota, residents over the 20 year period, 1960-79. One hundred and thirty eight cases met diagnostic and residency criteria, for an overall age, and sex adjusted chronic ulcerative colitis incidence rate of 15.0 per 100,000 person years. The male:female ratio of age adjusted rates was 1.5:1. Age specific incidence was roughly bimodal in appearance but was not consistent in different patient subgroups. On 1-1-80, there were 120 Rochester residents with a history of chronic ulcerative colitis, corresponding to a prevalence rate of 225.2 per 100,000 population. Fifty three per cent of chronic ulcerative colitis incidence cases were 'definite' and 47% were 'probable', the former requiring consistent observations for at least six months. The definite group had proportionately more men and disease of greater extent and severity. Pancolitis comprised about one-third of all cases (4.6 per 100,000 person years). Proctitis and distal disease (7.1 and 2.0 per 100,000 person years) made up most of the rest. One-fourth of all patients had 'severe' or 'moderate' disease (3.8 per 100,000 person years), while the remainder had either 'mild' or 'transient' chronic ulcerative colitis (11.2 per 100,000 person years). In residents of Rochester, Minnesota, chronic ulcerative colitis is most often a mild disease. The over-representation of severe or complicated examples that results from selected referral to major centres probably distorts the natural clinical spectrum of the disease.
利用罗切斯特流行病学项目基于人群的数据资源，我们确定了1960年至1979年这20年间明尼苏达州罗切斯特市居民中慢性溃疡性结肠炎的发病率和患病率。138例病例符合诊断和居住标准，年龄和性别调整后的慢性溃疡性结肠炎总体发病率为每10万人年15.0例。年龄调整率的男女比例为1.5:1。年龄别发病率在外观上大致呈双峰型，但在不同患者亚组中并不一致。1980年1月1日，有120名罗切斯特居民有慢性溃疡性结肠炎病史，患病率为每10万人225.2例。53%的慢性溃疡性结肠炎发病病例为“确诊”，47%为“可能”，前者需要至少6个月的持续观察。确诊组男性比例相对较高，疾病范围更广、病情更严重。全结肠炎约占所有病例的三分之一（每10万人年4.6例）。直肠炎和远端疾病（每10万人年7.1例和2.0例）占其余大部分。四分之一的患者患有“重度”或“中度”疾病（每10万人年3.8例），其余患者患有“轻度”或“短暂性”慢性溃疡性结肠炎（每10万人年11.2例）。在明尼苏达州罗切斯特市居民中，慢性溃疡性结肠炎最常为轻度疾病。因选择转诊至主要中心而导致的重度或复杂病例的过度代表可能会扭曲该疾病的自然临床谱。
