Programa de Pós-Graduação em Ciências Pneumológicas da Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.
Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Brazil.
J Med Virol. 2022 Nov;94(11):5279-5283. doi: 10.1002/jmv.27997. Epub 2022 Jul 19.
Vaccines are the most effective strategy to control the spread of coronavirus disease-2019 (COVID-19). Data on COVID-19 among healthcare workers (HCW) pre- and postvaccination are limited. This study aims to evaluate the clinical characteristics and outcomes of HCW with COVID-19 pre- and postvaccination. Retrospective cohort study. All HCWs with suspected COVID-19 were included. Demographic data, occupation, symptoms, work in COVID-19 area, and vaccination status were collected. There were 22 267 HCW visits for suspected COVID-19; 7879 (35.4%) tested positive, and 14 388 (64.6%) tested negative. Fever, cough, fatigue, and dyspnea were positive predictors of COVID-19, and sore throat, headache, coryza, work in a COVID-19 area, and COVID-19 vaccination were negative predictors. Of the total number of visits, 41.2% were from vaccinated HCW and 58.8% were from unvaccinated HCW. Among HCWs with COVID-19, 84 (1.1%) required hospitalization, 11 (0.1%) in an intensive care unit (ICU), with three (0.04%) deaths. Six hospitalizations occurred in vaccinated HCWs, being of short duration, with no need for ICU admission and no deaths. SARS-CoV-2 infection prevalence was high among HCW, and vaccinated HCW had fewer hospitalizations, need for ICU, and deaths. Therefore, vaccines may attenuate COVID-19 severity, and efforts must be concentrated to ensure adequate vaccination for HCW.
疫苗是控制 2019 年冠状病毒病（COVID-19）传播的最有效策略。关于 COVID-19 疫苗接种前后医护人员（HCW）的数据有限。本研究旨在评估 COVID-19 疫苗接种前后 HCW 的临床特征和结局。回顾性队列研究。所有疑似 COVID-19 的 HCW 均纳入研究。收集人口统计学数据、职业、症状、在 COVID-19 区工作情况和疫苗接种情况。共有 22267 名 HCW 因疑似 COVID-19 就诊；7879 例（35.4%）检测结果阳性，14388 例（64.6%）检测结果阴性。发热、咳嗽、乏力和呼吸困难是 COVID-19 的阳性预测因素，而咽痛、头痛、鼻塞、在 COVID-19 区工作和 COVID-19 疫苗接种是阴性预测因素。在总就诊人数中，41.2%来自已接种疫苗的 HCW，58.8%来自未接种疫苗的 HCW。在 COVID-19 患者中，84 例（1.1%）需要住院治疗，11 例（0.1%）需要入住重症监护病房（ICU），3 例（0.04%）死亡。6 例住院发生在已接种疫苗的 HCW 中，住院时间短，无需入住 ICU，也无死亡病例。COVID-19 感染在 HCW 中流行率较高，而接种疫苗的 HCW 住院、入住 ICU 和死亡人数较少。因此，疫苗可能减轻 COVID-19 的严重程度，必须集中精力确保 HCW 充分接种疫苗。
