ENDURAGen在α-半乳糖苷酶缺乏症中的移植物耐久性。
ENDURAGen graft durability in α-Gal disease.
作者信息
Ruland Kelly L, Kirzhner Maria
机构信息
Department of Ophthalmology, University of Virginia, Charlottesville, VA, 1300 Jefferson Park Avenue, Charlottesville, VA, 22903, USA.
出版信息
Am J Ophthalmol Case Rep. 2022 Jun 30;27:101637. doi: 10.1016/j.ajoc.2022.101637. eCollection 2022 Sep.
PURPOSE
We present a case of eyelid reconstruction using ENDURAGen, a porcine-derived acellular collagen graft, complicated by dissolution of the graft in a patient recently diagnosed with α-Gal disease.
OBSERVATIONS
A 33-year-old female status post enucleation of the left eye at age 7 struggling with malposition of her prosthesis due to lower lid retraction and laxity underwent eyelid reconstruction with ENDURAGen. She did well post-operatively for 9 months, but then began having issues with prosthesis dislodgement and rotation. Around that time, the patient was diagnosed with α-Gal disease. Repeat eyelid reconstruction was performed, this time with an ear cartilage graft, and dissolution of the original ENDURAGen graft was confirmed.
CONCLUSIONS AND IMPORTANCE
This case highlights the need for evaluation of the durability of ENDURAGen in patients with α-Gal and for caution in choosing porcine or bovine-derived implants for tissue reconstruction in this population.
目的
我们报告一例使用ENDURAGen（一种猪源脱细胞胶原移植物）进行眼睑重建的病例，该病例中移植物在一名近期被诊断为α - 半乳糖病的患者体内发生溶解。
观察结果
一名33岁女性，7岁时左眼摘除眼球，因下睑退缩和松弛导致义眼位置不正，接受了使用ENDURAGen的眼睑重建手术。术后9个月她恢复良好，但随后开始出现义眼移位和旋转问题。大约在那个时候，该患者被诊断出患有α - 半乳糖病。再次进行了眼睑重建手术，这次使用的是耳软骨移植物，并证实了原来的ENDURAGen移植物发生了溶解。
结论与意义
该病例强调了对α - 半乳糖病患者评估ENDURAGen耐久性的必要性，以及在为该人群选择猪或牛源植入物进行组织重建时需谨慎。
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