Du Wurong, Guo Kaibo, Jin Huimin, Sun Leitao, Ruan Shanming, Song Qiaoling
The First School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, China.
Department of Oncology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Front Oncol. 2022 Jun 27;12:928619. doi: 10.3389/fonc.2022.928619. eCollection 2022.
Metabolic syndrome (MetS) has been related to increased risks of a variety of cancers. However, the association between MetS and the risk of renal cell cancer (RCC) remains not fully determined. This meta-analysis was conducted to investigate whether MetS is independently associated with the risk of RCC in adults.
Relevant observational studies were obtained by searching PubMed, Embase, Cochrane's Library, and Web of Science databases. Study characteristics and outcome data were extracted independently by two authors. The random-effect model was used for meta-analysis considering the possible influence of between-study heterogeneity. Predefined subgroup analyses were used to evaluate the possible influences of study characteristics on the outcome.
Eight studies involving 10,601,006 participants contributed to the meta-analysis. Results showed that MetS was independently associated with a higher risk of RCC in adult population (risk ratio [RR]: 1.62, 95% confidence interval [CI]: 1.41 to 1.87, p<0.001; I = 85%). Subgroup analyses showed consistent association in men (RR: 1.52, 95% CI: 1.23 to 1.89, p<0.001) and in women (RR: 1.71, 95% CI: 1.28 to 2.27, p<0.001), in Asians (RR: 1.51, 95% CI: 1.25 to 1.83, p<0.001) and in Caucasians (RR: 1.76, 95% CI: 1.46 to 2.12, p<0.001), and in community derived (RR: 1.56, 95% CI: 1.34 to 1.82, p<0.001) and non-community derived population (RR: 1.87, 95% CI: 1.71 to 2.04, p<0.001). Differences in study design or quality score also did not significantly affect the association (p for subgroup difference both >0.05).
MetS may be independently associated with RCC in adult population.
代谢综合征（MetS）与多种癌症风险增加相关。然而，MetS与肾细胞癌（RCC）风险之间的关联仍未完全确定。本荟萃分析旨在调查MetS是否与成人RCC风险独立相关。
通过检索PubMed、Embase、Cochrane图书馆和Web of Science数据库获取相关观察性研究。研究特征和结局数据由两位作者独立提取。考虑到研究间异质性的可能影响，采用随机效应模型进行荟萃分析。使用预定义的亚组分析来评估研究特征对结局的可能影响。
八项研究涉及10601006名参与者，纳入了荟萃分析。结果显示，MetS与成人人群中较高的RCC风险独立相关（风险比[RR]：1.62，95%置信区间[CI]：1.41至1.87，p<0.001；I² = 85%）。亚组分析显示，在男性（RR：1.52，95%CI：1.23至1.89，p<0.001）和女性（RR：1.71，95%CI：1.28至2.27，p<0.001）、亚洲人（RR：1.51，95%CI：1.25至1.83，p<0.001）和白种人（RR：1.76，95%CI：1.46至2.12，p<0.001）、社区人群（RR：1.56，95%CI：1.34至1.82，p<0.001）和非社区人群（RR：1.87，95%CI：1.71至2.04，p<0.001）中均存在一致的关联。研究设计或质量评分的差异也未显著影响该关联（亚组差异的p值均>0.05）。
MetS可能与成人人群的RCC独立相关。
