Watanabe Jun, Kotani Kazuhiko
Division of Community and Family Medicine, Jichi Medical University, Shimotsuke city, Japan.
Arch Med Sci. 2021 Mar 21;18(4):958-964. doi: 10.5114/aoms/130288. eCollection 2022.
is a bacterium that causes chronic gastroduodenal infection and affects various systemic diseases. An increase in the blood level of C-reactive protein (CRP; a systemic inflammatory marker), at a low-grade chronic inflammation level, is observed in cases of infection. However, the effect of eradication on CRP remains undetermined. Therefore, we aimed to evaluate the circulating CRP levels in eradicated patients through a meta-analysis.
The PubMed database was searched from its inception to June 2020. Studies that described the CRP levels following eradication were collected. A random-effects meta-analysis was then performed using inverse variance with standardized mean difference.
A total of 10 eligible studies (642 subjects in total) were available. The median age in the studies was 49.9 years. The CRP level was 6.0 (median) mg/l before eradication and 5.8 (median) mg/l after eradication. From the results of the overall meta-analysis, there was found to be a significant reduction in the CRP levels with eradication (standardized mean difference: -0.64; 95% confidence interval: -1.02 to -0.27). The result was not similarly confirmed in a subanalysis of the available randomized controlled trials.
Weak evidence exists regarding the effects of eradication on CRP levels. Further research is called for.
[某种细菌名称]是一种可引起慢性胃十二指肠感染并影响多种全身性疾病的细菌。在感染病例中，可观察到在低度慢性炎症水平下，C反应蛋白（CRP；一种全身性炎症标志物）的血液水平会升高。然而，根除[细菌名称]对CRP的影响仍未确定。因此，我们旨在通过荟萃分析评估根除[细菌名称]的患者的循环CRP水平。
检索了从PubMed数据库建立至2020年6月的文献。收集了描述根除[细菌名称]后CRP水平的研究。然后使用逆方差和标准化均差进行随机效应荟萃分析。
共有10项符合条件的研究（共642名受试者）。这些研究中的中位年龄为49.9岁。根除[细菌名称]前CRP水平中位数为6.0mg/l，根除后为5.8mg/l。从总体荟萃分析结果来看，根除[细菌名称]后CRP水平有显著降低（标准化均差：-0.64；95%置信区间：-1.02至-0.27）。在现有随机对照试验的亚分析中未得到类似的证实结果。
关于根除[细菌名称]对CRP水平的影响，证据不足。需要进一步研究。
