Baye Gelagey, Wondmneh Bayu, Ashenef Baye, Jemal Mohammed, Baylie Temesgen
Department of Biomedical Science, Debre Markos University, Debre Markos, Ethiopia.
Front Cardiovasc Med. 2024 Sep 26;11:1470993. doi: 10.3389/fcvm.2024.1470993. eCollection 2024.
Dyspepsia is a group of symptoms located in the gastroduodenal area of the upper gastrointestinal tract characterized by epigastric pain, postprandial completeness, or early satiety and occasionally related to heartburn. is the major causative agent of dyspepsia and gastric-related disorders; besides, it alters different metabolic processes in the human body, such as lipid metabolism and inflammatory processes. Even though dyslipidemia and inflammation are independent risk factors for cardiovascular disorders, we are assessing the interaction between serum lipids and highly sensitive C reactive protein levels among dyspeptic patients to predict potential cardiovascular disorders.
To assess serum high sensitive C reactive protein levels and its correlation with lipid profile among dyspeptic patients.
A hospital-based comparative cross-sectional study was conducted from May 2022 to March 2023 in East Gojjam, Ethiopia. One hundred -positive and 100 -negative dyspeptic patients were included. Data were checked for completeness and entered into SPSS version 26.0 software and analyzed. The association between variables was determined by Pearson correlation analysis. A -value <0.05 was considered statistically significant.
The mean serum high sensitive C reactive protein was 8.09 ± 7.84 mg/L, and serum high-density lipoprotein, low-density lipoprotein, total cholesterol, and triglyceride were (35.35 ± 7.5, 105.07 ± 87.63, 142.31 ± 71.31, 160.07 ± 43.06) mg/dl, respectively, for positive dyspeptic patients. Among these values, high-density lipoprotein is negatively correlated with high sensitive C reactive and total cholesterol is positively correlated with high sensitive C reactive levels among -infected dyspeptic patients with a -value < 0.05, but in negative dyspeptic patients, there is no significant correlation between lipid profile and high sensitive C reactive levels.
Serum high sensitive C reactive levels had a negative correlation with high-density lipoprotein and a positive correlation with total cholesterol among -positive dyspeptic patients. Therefore, the significant interaction between serum lipid levels and inflammation exacerbates the potential risk of cardiovascular disorders among -positive dyspeptic patients.
消化不良是一组位于上消化道胃十二指肠区域的症状，其特征为上腹部疼痛、餐后饱胀或早饱，偶尔与烧心有关。幽门螺杆菌是消化不良和胃部相关疾病的主要致病因素；此外，它会改变人体不同的代谢过程，如脂质代谢和炎症过程。尽管血脂异常和炎症是心血管疾病的独立危险因素，但我们正在评估消化不良患者血清脂质与高敏C反应蛋白水平之间的相互作用，以预测潜在的心血管疾病。
评估消化不良患者血清高敏C反应蛋白水平及其与血脂谱的相关性。
2022年5月至2023年3月在埃塞俄比亚东戈贾姆进行了一项基于医院的比较横断面研究。纳入100例幽门螺杆菌阳性和100例幽门螺杆菌阴性的消化不良患者。检查数据的完整性并录入SPSS 26.0软件进行分析。变量之间的关联通过Pearson相关分析确定。P值<0.05被认为具有统计学意义。
幽门螺杆菌阳性消化不良患者的血清高敏C反应蛋白平均为8.09±7.84mg/L，血清高密度脂蛋白、低密度脂蛋白、总胆固醇和甘油三酯分别为（35.35±7.5、105.07±87.63、142.31±71.31、160.07±43.06）mg/dl。在这些值中，幽门螺杆菌感染的消化不良患者中，高密度脂蛋白与高敏C反应蛋白呈负相关，总胆固醇与高敏C反应蛋白水平呈正相关，P值<0.05，但在幽门螺杆菌阴性的消化不良患者中，血脂谱与高敏C反应蛋白水平之间无显著相关性。
幽门螺杆菌阳性的消化不良患者中，血清高敏C反应蛋白水平与高密度脂蛋白呈负相关，与总胆固醇呈正相关。因此，血清脂质水平与炎症之间的显著相互作用加剧了幽门螺杆菌阳性消化不良患者发生心血管疾病的潜在风险。
