Casseb Jorge, Lopes Luciano Rodrigo
Laboratory of Dermatology and Immunodeficiencies, Department of Dermatology, University of São Paulo Medical School, Brazil/Institute of Tropical Medicine of São Paulo, São Paulo, Brazil.
Bioinformatics and Biomedical Data Science Division, Health Informatics Department, Federal University of Sao Paulo-Unifesp, São Paulo, Brazil.
AIDS Res Hum Retroviruses. 2022 Dec;38(12):933-938. doi: 10.1089/AID.2022.0019. Epub 2022 Aug 29.
During millions of years, viruses have emerged and reemerged, with imbalance of photogenicity and transmissivity overtime. This letter describes that sometimes the nomenclature is uncertain what may actually happen during retrovirus evolution nowadays. This article discusses a possibility that human T-lymphotropic virus type 2 (HTLV-2) has been processed to incorporate the human genome in the last millions of years. Persistent viruses such as human immunodeficiency virus type 1 (HIV-1), HIV-2, and human T cell lymphotropic type 2 may also have potential of endogenization instead of a cytolytic process in a long time.
在数百万年的时间里，病毒不断出现和再次出现，其致病性和传播性随时间而失衡。这封信描述了如今在逆转录病毒进化过程中，有时命名并不确定实际会发生什么。本文讨论了一种可能性，即人类嗜T淋巴细胞病毒2型（HTLV-2）在过去数百万年中已被整合到人类基因组中。诸如人类免疫缺陷病毒1型（HIV-1）、HIV-2和人类嗜T淋巴细胞病毒2型等持续性病毒在很长一段时间内也可能具有内源性而非溶细胞过程的潜力。
