Department of Community Oral Health, School of Dentistry, Asahi University, Mizuho, Gifu, Japan.
Asahi University Hospital, Gifu, Japan.
PLoS One. 2022 Jul 14;17(7):e0271459. doi: 10.1371/journal.pone.0271459. eCollection 2022.
Helicobacter pylori (H. pylori) is widely known as a cause of gastric disorders. Presence of H. pylori in dental pulp has been reported. Dental caries may influence the presence or absence of systemic H. pylori infection by serving as a source of H. pylori. In this cross-sectional study, we examined whether H. pylori infection in blood were associated with dental caries in Japanese adults. The participants were 752 individuals (513 males and 239 females, mean age 53.8 years) who underwent both H. pylori testing (H. pylori antibody test and pepsinogen test) and dental checkups at the Asahi University Hospital Human Health Center between April 2018 and March 2019. Those diagnosed as positive for H. pylori antibody test or positive for serum pepsinogen test as H. pylori test in the human health checkup were judged as those with H. pylori infection in the blood. In our study, 83 participants (11%) were determined to be infected with H. pylori in the blood. The proportion of those with decayed teeth was higher in participants with H. pylori infection in blood than in those without H. pylori infection in blood (p< 0.001). The logistic analysis showed that presence of H. pylori infection in blood was positively associated with those with decayed teeth (OR, 5.656; 95% CI, 3.374 to 9.479) after adjusting for age, gender, gastric disease, regular dental checkups, antibiotic medication history, and decayed teeth. Furthermore, the proportion of H. pylori infection in blood increased according to number of decayed teeth (p< 0.001). The results indicate that H. pylori infection in blood were associated with decayed teeth. Untreated dental caries may have an impact on systemic H. pylori infection.
幽门螺杆菌（H. pylori）被广泛认为是引起胃部疾病的原因。有报道称，牙髓中存在 H. pylori。龋齿可能通过成为 H. pylori 的来源，影响全身 H. pylori 感染的存在与否。在这项横断面研究中，我们研究了日本成年人血液中 H. pylori 感染是否与龋齿有关。参与者为 752 人（男性 513 人，女性 239 人，平均年龄 53.8 岁），他们于 2018 年 4 月至 2019 年 3 月期间在朝日大学医院人类健康中心同时接受了 H. pylori 检测（H. pylori 抗体检测和胃蛋白酶原检测）和牙科检查。在健康检查中，H. pylori 抗体检测或血清胃蛋白酶原检测阳性的人被判定为血液中存在 H. pylori 感染。在我们的研究中，83 名参与者（11%）被确定为血液中存在 H. pylori 感染。与血液中无 H. pylori 感染的参与者相比，血液中有 H. pylori 感染的参与者中患有龋齿的比例更高（p<0.001）。经年龄、性别、胃部疾病、定期牙科检查、抗生素用药史和龋齿调整后，logistic 分析显示，血液中有 H. pylori 感染与患有龋齿呈正相关（OR，5.656；95%CI，3.374 至 9.479）。此外，血液中 H. pylori 感染的比例随着龋齿数量的增加而增加（p<0.001）。结果表明，血液中 H. pylori 感染与龋齿有关。未经治疗的龋齿可能对全身 H. pylori 感染产生影响。
