BACKGROUND: Osteoarthritis (OA), the most prevalent form of arthritis, which affects up to 15% of the adult population. The work presented in this paper focuses on the analysis of the publications on osteoimmunology of OA. The purpose of this paper is to provide inspiration for future research on osteoimmunology of OA. METHODS: We extracted all of the English publications relevant to osteoimmunology of OA published from 1991-2020 from the Web of Science. SPSS, GraphPad Prism, Citespace, and VOSviewer were utilized to collect and analyze the publication trends in osteoimmunology of OA. RESULTS: We identified a total number of 1,004 publications with a total number of citations of 35,675 by October 31, 2020. Most publications came from China (26.8%). The United States ranked second, but its average number of citations and H index ranked best (10,130 citations and 55 H-index). Shandong University is the main center of institutional cooperation. Most papers related to osteoimmunology of OA were published in the journal of . In this field, TAK PP published the most papers (15), while Kotake, S's article was cited the most frequently (1,195). As presented in Figure 6, the 70 keywords, defined as terms that appeared more than 50 times in all papers, were classified into four clusters molecular research, human research, animal research and cell research. Research on cytokines and pathways is the new trend in Molecular research. CONCLUSION: The current status and global trend of osteoimmunology of OA revealed by this study indicates that there is a strong possibility that the number of papers will increase in the coming year, and the research on cytokines as well as pathways would be the next hot topic.