Key Laboratory of Functional Polymer Materials of Ministry of Education, State Key Laboratory of Medicinal Chemical Biology, Institute of Polymer Chemistry and College of Chemistry, Nankai University, Tianjin, 300071, P. R. China.
State Key Laboratory of Separation Membranes and Membrane Processes and School of Materials Science and Engineering, Tiangong University, Tianjin, 300387, P. R. China.
Small. 2022 Aug;18(32):e2203100. doi: 10.1002/smll.202203100. Epub 2022 Jul 17.
Personalized cancer vaccination using nanomaterials holds great potential for cancer immunotherapy. Here, a nanochaperone (PBA-nChap) is tailored for in situ capture of tumor-associated antigens (TAAs) to improve cancer immunotherapy. The PBA-nChap is capable of i) efficiently capturing TAAs in situ; ii) protecting TAAs from degradation; iii) transporting TAAs to antigen-presenting cells and promoting cross-presentation. Intratumor injection of PBA-nChap in combination with pretreatment with photodynamic therapy (PDT) significantly enhances immune response and exhibits excellent antitumor efficacy. Moreover, nanovaccine prepared by simply co-culturing PBA-nChap with tumor cell fragments from surgery resected primary tumor in vitro synergized with immune checkpoint blockade (ICB) therapy can effectively inhibit tumor recurrence and metastasis after an operation. This work provides a promising platform for personalized cancer vaccination.
利用纳米材料进行个体化癌症疫苗接种在癌症免疫治疗方面具有巨大潜力。在这里，一种纳米伴侣（PBA-nChap）被设计用于原位捕获肿瘤相关抗原（TAAs），以提高癌症免疫治疗效果。PBA-nChap 能够：i）高效原位捕获 TAA；ii）保护 TAA 免受降解；iii）将 TAA 转运至抗原呈递细胞并促进交叉呈递。肿瘤内注射 PBA-nChap 联合光动力治疗（PDT）预处理可显著增强免疫反应，并表现出优异的抗肿瘤疗效。此外，通过简单地将 PBA-nChap 与手术切除的原发性肿瘤细胞碎片在体外共培养制备的纳米疫苗与免疫检查点阻断（ICB）治疗协同作用，可有效抑制手术后的肿瘤复发和转移。这项工作为个体化癌症疫苗接种提供了一个有前途的平台。
