School of Chinese Materia Medica, Guangdong Pharmaceutical University, Guangzhou, China.
Key Laboratory of Digital Quality Evaluation of Chinese Materia Medica of State Administration of TCM, Guangdong Pharmaceutical University, Guangzhou, China.
Phytother Res. 2022 Sep;36(9):3490-3504. doi: 10.1002/ptr.7555. Epub 2022 Jul 17.
Eleutherococcus senticosus is a medicinal plant widely used in traditional medicine and edible remedies with effects on anti-fatigue, sleep improvement, and memory enhancement. Recently, the application of E. senticosus to neurological disorders has been a focus. However, its overall pharmacological effect on neural diseases and relevant mechanisms are needed in an in-depth summary. In this review, the traditional uses and the therapeutic effect of E. senticosus on the treatment of fatigue, depression, Alzheimer's disease, Parkinson's disease, and cerebral ischemia were summarized. In addition, the underlying mechanisms involved in the anti-oxidative damage, anti-inflammation, neurotransmitter modulation, improvement of neuronal growth, and anti-apoptosis were discussed. This review will accelerate the understanding of the neuroprotective effects brought from the E. senticosus, and impetus its development as a phytotherapy agent against neurological disorders.
刺五加是一种药用植物，广泛应用于传统医学和食疗中，具有抗疲劳、改善睡眠和增强记忆力的作用。最近，刺五加在神经紊乱方面的应用成为研究热点。然而，需要对其在神经疾病方面的整体药理作用和相关机制进行深入总结。本综述总结了刺五加在抗疲劳、抗抑郁、阿尔茨海默病、帕金森病和脑缺血方面的传统用途和治疗效果。此外，还讨论了其发挥抗氧化损伤、抗炎、调节神经递质、促进神经元生长和抗细胞凋亡作用的潜在机制。本综述将加速人们对刺五加神经保护作用的理解，并推动其作为治疗神经紊乱的植物疗法药物的发展。
