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二陈汤改善高脂饮食喂养大鼠的代谢异常。

Erchen Decoction Ameliorates the Metabolic Abnormalities of High-Fat Diet-Fed Rats.

机构信息

The Research Center of Basic Integrative Medicine, Basic Medical College, Guangzhou University of Chinese Medicine, University Town, Guangzhou 510006, China.

Department of Physiology, Basic Medical College, Guangzhou University of Chinese Medicine, University Town, Guangzhou 510006, China.

出版信息

Comput Math Methods Med. 2022 Jul 6;2022:2183542. doi: 10.1155/2022/2183542. eCollection 2022.

DOI:10.1155/2022/2183542
PMID:35844447
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9279095/
Abstract

OBJECTIVE

Brown adipose tissue (BAT) dissipates chemical energy to protect against obesity. In the present study, we aimed to determine the effects of Erchen decoction on the lipolysis and thermogenesis function of BAT in high-fat diet-fed rats.

METHODS

Sprague-Dawley rats were randomly divided into four groups, which were fed a control diet (C) or a high-fat diet (HF), and the latter was administered with high and low doses of Erchen decoction by gavage once a day, for 12 weeks. Body weight, the serum lipid profile, serum glucose, and insulin levels of the rats were evaluated. In addition, the phosphorylation and protein and mRNA expression of AMP-activated protein kinase (AMPK), adipose triglyceride lipase (ATGL), peroxisome proliferator-activated receptor coactivator- (PGC-) 1, and uncoupling protein 1 (UCP-1) in BAT were measured by immunoblotting and RT-PCR.

RESULTS

Erchen decoction administration decreased body weight gain and ameliorated the abnormal lipid profile and insulin resistance index of the high-fat diet-fed rats. In addition, the expression of p-AMPK and ATGL in the was significantly increased by Erchen decoction. Erchen decoction also increased the protein and mRNA expression of PGC-1 and UCP-1 in BAT.

CONCLUSION

Erchen decoction ameliorates the metabolic abnormalities of high-fat diet-fed rats, at least in part activation of lipolysis and thermogenesis in BAT.

摘要

目的

棕色脂肪组织（BAT）消耗化学能量以预防肥胖。本研究旨在确定二陈汤对高脂肪饮食喂养大鼠 BAT 脂肪分解和产热功能的影响。

方法

将 Sprague-Dawley 大鼠随机分为四组，分别给予对照饮食（C）或高脂肪饮食（HF），后者通过灌胃每天给予高、低剂量的二陈汤，共 12 周。评估大鼠的体重、血清脂质谱、血清葡萄糖和胰岛素水平。此外，通过免疫印迹和 RT-PCR 测量 BAT 中 AMP 激活的蛋白激酶（AMPK）、脂肪甘油三酯脂肪酶（ATGL）、过氧化物酶体增殖物激活受体共激活因子-1（PGC-1）和解偶联蛋白 1（UCP-1）的磷酸化和蛋白及 mRNA 表达。

结果

二陈汤给药可降低体重增加，并改善高脂肪饮食喂养大鼠的异常脂质谱和胰岛素抵抗指数。此外，二陈汤可显著增加 BAT 中 p-AMPK 和 ATGL 的表达。二陈汤还增加了 BAT 中 PGC-1 和 UCP-1 的蛋白和 mRNA 表达。

结论

二陈汤改善了高脂肪饮食喂养大鼠的代谢异常，至少部分通过激活 BAT 中的脂肪分解和产热作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69c4/9279095/9132e061d0bb/CMMM2022-2183542.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69c4/9279095/ef202dc2f360/CMMM2022-2183542.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69c4/9279095/c470de06073f/CMMM2022-2183542.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69c4/9279095/7fa82e10188d/CMMM2022-2183542.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69c4/9279095/0d49b54df74b/CMMM2022-2183542.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69c4/9279095/9132e061d0bb/CMMM2022-2183542.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69c4/9279095/ef202dc2f360/CMMM2022-2183542.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69c4/9279095/c470de06073f/CMMM2022-2183542.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69c4/9279095/7fa82e10188d/CMMM2022-2183542.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69c4/9279095/0d49b54df74b/CMMM2022-2183542.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69c4/9279095/9132e061d0bb/CMMM2022-2183542.005.jpg

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