Rizwan Ahmad Abdul Momin, Farooq Umar, Anees Mariam, Anis Riffat Aysha, Rashid Summer, Ahmed Waqas
Department of Nutrition & Dietetics National University of Medical Sciences (NUMS) Rawalpindi Pakistan.
Department of Diet and Nutritional Sciences IBADAT International University Islamabad Pakistan.
Food Sci Nutr. 2022 May 7;10(7):2141-2148. doi: 10.1002/fsn3.2337. eCollection 2022 Jul.
Micronutrient deficiencies affect approximately 2 billion people worldwide and iron deficiency anemia is one of them. The instant research was an attempt to determine the efficacy of co-administration of two iron fortificants (NaFeEDTA and FeSO) and inulin (a prebiotic) on serum iron, ferritin, transferrin, and total iron-binding capacity in iron-deficient female Sprague Dawley rats. For this research, rats were divided into ten groups, (two control and eight treatment groups). Treatment groups were made iron deficient by feeding them with triapine, an iron binder for two weeks. All treatment groups were fed with inulin at two different dosage levels along with iron fortificants. The study results showed that serum ferritin and serum iron levels significantly improved from initiation to termination of study. Also, mean values of total iron-binding capacity and serum transferrin showed a steady decline over a period of three months indicating that iron stores were being improved. It was concluded that co-administration of inulin and iron fortificants helped improve iron deficiency biomarkers in female Sprague Dawley rats.
全球约有20亿人受微量营养素缺乏影响，缺铁性贫血便是其中之一。本即时研究旨在确定两种铁强化剂（乙二胺四乙酸铁钠和硫酸亚铁）与菊粉（一种益生元）联合使用对缺铁雌性斯普拉格-道利大鼠血清铁、铁蛋白、转铁蛋白和总铁结合力的功效。在本研究中，大鼠被分为十组（两组对照组和八组治疗组）。通过给治疗组大鼠喂食铁螯合剂曲安西平两周使其缺铁。所有治疗组均喂食两种不同剂量水平的菊粉以及铁强化剂。研究结果表明，从研究开始到结束，血清铁蛋白和血清铁水平显著改善。此外，总铁结合力和血清转铁蛋白的平均值在三个月内呈稳步下降趋势，表明铁储备正在改善。得出的结论是，菊粉与铁强化剂联合使用有助于改善雌性斯普拉格-道利大鼠的缺铁生物标志物。
