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小儿阑尾炎中的肠道微生物群与炎症因子

The Gut Microbiota and Inflammatory Factors in Pediatric Appendicitis.

作者信息

Bi Yuewei, Yang Qianyu, Li Jiao, Zhao Xufeng, Yan Beilei, Li Xuan, Cui Hualei

机构信息

Department of the Graduate School, Tianjin Medical University, Tianjin, China.

Department of Internal Medicine, Tianjin Children's Hospital (Children's Hospital of Tianjin University), Tianjin, China.

出版信息

Dis Markers. 2022 Jul 7;2022:1059445. doi: 10.1155/2022/1059445. eCollection 2022.

DOI:10.1155/2022/1059445
PMID:35845131
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9282992/
Abstract

BACKGROUND

The study analyzed gut microflora's composition and investigated the associations between the associations between gut dysbiosis and inflammatory indicators in pediatric patients with acute appendicitis.

METHODS

High-throughput sequencing and bioinformatics analysis were used to investigate the composition and diversity of gut microflora in 20 pediatric patients with acute appendicitis and 11 healthy children. Endpoints measured were operational taxonomic units (OTU) of gut microflora. The OTU and its abundance analysis, sample diversity analysis, principal component analysis of samples, differential analysis, and analysis of biomarkers were performed.

RESULTS

Overall fecal microbial richness and diversity were similar in patients and controls. Yet richness within the group of Bilophila, Eggerthella, Clostridium, Parvimonas, Megasphaera, Atopobium, Phascolarctobacterium, Adlercreutzia, Barnesiella, Klebsiella, Enterococcus, and Prevotella genera was higher in patients. Adlercreutzia was significantly positively correlated with IL-10, while the three other genera, comprising Klebsiella, Adlercreutzia, and Prevotella, were positively correlated with B cells level.

CONCLUSION

Gut microbiome components are significantly different in pediatric patients with acute appendicitis and healthy children. The differential abundance of some genera is correlated with the production of inflammatory markers in appendicitis.

摘要

背景

本研究分析了小儿急性阑尾炎患者肠道微生物群的组成，并调查了肠道菌群失调与炎症指标之间的关联。

方法

采用高通量测序和生物信息学分析方法，对20例小儿急性阑尾炎患者和11例健康儿童的肠道微生物群的组成和多样性进行研究。测量的终点是肠道微生物群的可操作分类单元（OTU）。进行了OTU及其丰度分析、样本多样性分析、样本主成分分析、差异分析和生物标志物分析。

结果

患者和对照组的粪便微生物总体丰富度和多样性相似。然而，在嗜胆菌属、埃格特菌属、梭菌属、微小单胞菌属、巨球型菌属、阿托波氏菌属、考拉杆菌属、阿德勒克雷茨菌属、巴内西菌属、克雷伯菌属、肠球菌属和普雷沃菌属中，患者组的丰富度更高。阿德勒克雷茨菌属与IL-10呈显著正相关，而包括克雷伯菌属、阿德勒克雷茨菌属和普雷沃菌属在内的其他三个菌属与B细胞水平呈正相关。

结论

小儿急性阑尾炎患者和健康儿童的肠道微生物群组成存在显著差异。一些菌属的差异丰度与阑尾炎中炎症标志物的产生相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e35/9282992/09db6b792909/DM2022-1059445.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e35/9282992/4c72fa26ffc8/DM2022-1059445.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e35/9282992/207a85d135b4/DM2022-1059445.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e35/9282992/b6aff3c860a9/DM2022-1059445.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e35/9282992/505a88ab4a3b/DM2022-1059445.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e35/9282992/9fc5d446643d/DM2022-1059445.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e35/9282992/09db6b792909/DM2022-1059445.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e35/9282992/4c72fa26ffc8/DM2022-1059445.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e35/9282992/207a85d135b4/DM2022-1059445.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e35/9282992/b6aff3c860a9/DM2022-1059445.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e35/9282992/505a88ab4a3b/DM2022-1059445.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e35/9282992/9fc5d446643d/DM2022-1059445.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e35/9282992/09db6b792909/DM2022-1059445.006.jpg

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