Wan Muhd Shukeri Wan Fadzlina, Mat Nor Mohd Basri, Md Ralib Azrina
Department of Anaesthesiology and Intensive Care, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia.
Department of Anaesthesiology and Critical Care, Kuliyyah of Medicine, International Islamic Universiti Malaysia, Pahang, Malaysia.
Malays J Med Sci. 2022 Jun;29(3):145-150. doi: 10.21315/mjms2022.29.3.14. Epub 2022 Jun 28.
Sepsis is an important cause of morbidity and mortality in elderly patients, but there is a scarcity of data on sepsis in this specific cohort. We performed this study to review the impact of sepsis on outcomes in elderly patients admitted to our local intensive care unit (ICU). This was a secondary analysis of prospectively collected data of 159 consecutive adult patients with sepsis admitted to an ICU of a tertiary hospital in Malaysia over a three-year period. Of the 159 patients analysed, elderly patients constituted 18.9% of the cohort. Fifty percent of the older patients died within 30 days, compared to 24% of younger patients ( = 0.005). On multivariate analysis, old age was found to be independently predictive of 30-day mortality with an adjusted odds ratio (OR) of 2.5 (95% confidence interval [CI]: 1.05, 6.01) compared to younger patients ( = 0.021). In a Kaplan-Meier analysis, survival probability was significantly lower in patients of an older age compared to younger patients ( = 0.015). In conclusion, mortality from sepsis is considerably higher in elderly patients, with age as an independent risk factor for mortality.
脓毒症是老年患者发病和死亡的重要原因，但针对这一特定人群的脓毒症数据匮乏。我们开展本研究以评估脓毒症对入住本地重症监护病房（ICU）的老年患者预后的影响。这是一项对前瞻性收集的数据进行的二次分析，数据来自马来西亚一家三级医院ICU在三年期间连续收治的159例成年脓毒症患者。在分析的159例患者中，老年患者占该队列的18.9%。50%的老年患者在30天内死亡，而年轻患者的这一比例为24%（P = 0.005）。多因素分析显示，与年轻患者相比，老年是30天死亡率的独立预测因素，校正比值比（OR）为2.5（95%置信区间[CI]：1.05，6.01）（P = 0.021）。在Kaplan-Meier分析中，老年患者的生存概率显著低于年轻患者（P = 0.015）。总之，老年患者因脓毒症导致的死亡率相当高，年龄是死亡的独立危险因素。
