Towner Mary, Novak Karen, Chae Young Kwang, Matei Daniela
Division of Gynecologic Oncology, Northwestern University, Chicago, IL 60611, USA.
Division of Hematology/Oncology, Northwestern University, Chicago, IL 60611, USA.
Gynecol Oncol Rep. 2022 Jul 8;42:101039. doi: 10.1016/j.gore.2022.101039. eCollection 2022 Aug.
Neuroendocrine carcinoma of the cervix is a rare subtype of cervical cancer with a poor prognosis. Primary treatment of this disease involves a combination of surgery, chemotherapy, and radiation. The majority of patients will experience disease recurrence, for which there exist no treatment guidelines. Because of histologic similarities, small cell lung cancer has often informed management of extrapulmonary neuroendocrine carcinomas. Immunotherapy regimens, including a combination of ipilimumab and nivolumab, have been shown to have activity in small cell lung cancer. In this report, we present the cases of 3 patients with recurrent neuroendocrine carcinoma of the cervix who experienced durable response to a combination of ipilimumab and nivolumab.
宫颈神经内分泌癌是宫颈癌的一种罕见亚型，预后较差。该疾病的主要治疗方法包括手术、化疗和放疗。大多数患者会出现疾病复发，目前尚无针对复发的治疗指南。由于组织学相似性，小细胞肺癌常为肺外神经内分泌癌的治疗提供参考。免疫治疗方案，包括伊匹木单抗和纳武单抗联合使用，已被证明在小细胞肺癌中具有活性。在本报告中，我们介绍了3例复发性宫颈神经内分泌癌患者的病例，这些患者对伊匹木单抗和纳武单抗联合治疗产生了持久反应。
