Bosworth Andrew, Wakerley Dominic, Houlihan Catherine F, Atabani Sowsan F
Infection Service, Clinical Laboratory Services, Queen Elizabeth Hospital, University Hospitals Birmingham NHS Foundation Trust, B15 2GW, UK.
Rare and Imported Pathogens Laboratory, UK Health Security Agency, Porton Down, Manor Farm Road, Salisbury, SP4 0JG, UK.
Infect Prev Pract. 2022 Jun 30;4(3):100229. doi: 10.1016/j.infpip.2022.100229. eCollection 2022 Sep.
At first glance, a multi-country outbreak of monkeypox in 2022 seems unusual. However, the re-emergence and expansion of this viral disease beyond its endemicity in West and Central Africa had previously been predicted as a possible consequence of a decline in population immunity following smallpox eradication. Since the 13th of May 2022, cases of monkeypox have been reported in at least 28 WHO member states from within 4 regions (the Americans, European, Eastern Mediterranean and Western Pacific regions). This summary describes the multi-country outbreak to date, with an emphasis on patient demographics, common symptoms and signs, clinical management (including infection prevention measures) and clinical outcomes of the cases in the United Kingdom, which has so far reported the largest number of laboratory confirmed cases. The future implications of this outbreak, including preventative measures to curb the current outbreak, prevent future outbreaks and the likelihood of the disease becoming endemic in the UK are also discussed.
乍一看，2022年多国爆发的猴痘疫情似乎不同寻常。然而，这种病毒性疾病在西非和中非的地方性流行范围之外再次出现并扩大，此前曾被预测为天花根除后人群免疫力下降可能导致的后果。自2022年5月13日以来，至少4个区域（美洲、欧洲、东地中海和西太平洋区域）的28个世卫组织成员国报告了猴痘病例。本综述描述了迄今为止的多国疫情，重点关注患者人口统计学、常见症状和体征、临床管理（包括感染预防措施）以及英国病例的临床结局，英国迄今报告的实验室确诊病例数量最多。还讨论了此次疫情的未来影响，包括遏制当前疫情、预防未来疫情的预防措施以及该疾病在英国成为地方性流行病的可能性。
