Chen Yan, Zhang Pingping, Lv Shunli, Su Xiaoju, Du Yiqi, Xu Can, Jin Zhendong
Department of Gastroenterology and Digestive Endoscopy Center, Changhai Hospital, Naval Medical University, Shanghai, China.
Endosc Ultrasound. 2022 Sep-Oct;11(5):407-413. doi: 10.4103/EUS-D-21-00167.
The positive energy balance between caloric intake and caloric output increasing storage of triglycerides (TG) in adipocytes has made nonalcoholic fatty liver disease (NAFLD) one of the major public health problems in China. Excessive lipid deposition in the pancreas is referred to as nonalcoholic fatty pancreas disease (NAFPD). Early assessment of pancreatic fat infiltration will have an increasing role in the clinical management of the metabolic dysregulation and prevention pancreatic complications.
We retrospectively collected data of inpatients with NAFPD from EUS database between September 2012 and August 2020 at our endoscopic center. The prevalence of NAFPD and factors associated with its development were statistically analyzed. The echogenicity of the pancreas was compared to that of the left renal cortex during the EUS examination by using an existing criterion.
Four thousand, seven hundred and four consecutive individuals underwent EUS were enrolled. The prevalence of NAFPD was 1.2% (57/4704) . Factors independently associated with NAFPD on multivariate analysis were increasing TG (odds ratios [OR] 4.65, P = 0.014), NAFLD (OR 16.76, P = 0.005) and decreasing apolipoprotein A-1 (OR 0.002, P = 0.0127). We found no association between NAFPD and age, sex, total cholesterol or hypertension.
We found a meaningful relationship between NAFLD, dyslipidemia, and NAFPD in Chinese. We hypothesized that NAFPD was strongly correlated with ectopic fat deposition and its related abnormalities of lipid metabolism. Early diagnosis of NAFLD provides opportunities to control the progression of NAFPD.
热量摄入与热量消耗之间的正能量平衡增加了甘油三酯（TG）在脂肪细胞中的储存，这使得非酒精性脂肪性肝病（NAFLD）成为中国主要的公共卫生问题之一。胰腺中脂质过度沉积被称为非酒精性脂肪性胰腺病（NAFPD）。胰腺脂肪浸润的早期评估在代谢失调的临床管理和预防胰腺并发症方面将发挥越来越重要的作用。
我们回顾性收集了2012年9月至2020年8月期间在我们内镜中心的EUS数据库中NAFPD住院患者的数据。对NAFPD的患病率及其发展相关因素进行了统计分析。在EUS检查期间，通过使用现有标准将胰腺的回声与左肾皮质的回声进行比较。
连续4704人接受了EUS检查并被纳入研究。NAFPD的患病率为1.2%（57/4704）。多变量分析中与NAFPD独立相关的因素包括TG升高（优势比[OR]4.65，P = 0.014）、NAFLD（OR 16.76，P = 0.005）和载脂蛋白A-1降低（OR 0.002，P = 0.0127）。我们发现NAFPD与年龄、性别、总胆固醇或高血压之间没有关联。
我们发现中国人群中NAFLD、血脂异常和NAFPD之间存在有意义的关系。我们推测NAFPD与异位脂肪沉积及其相关的脂质代谢异常密切相关。NAFLD的早期诊断为控制NAFPD的进展提供了机会。
