School of Dentistry, São Paulo State University (UNESP), São Paulo, Brazil.
Phytother Res. 2022 Sep;36(9):3415-3443. doi: 10.1002/ptr.7541. Epub 2022 Jul 18.
Thymol (THY) exhibits antibacterial and antioxidant properties. Recent studies have also shown that THY presents anti-inflammatory and healing properties. This review focused on in vitro and in vivo investigations related to THY utilization, as an anti-inflammatory and/or wound healing agent. PubMed, WebOfScience, and Scopus were examined. Independent reviewers conducted all diagram steps. PRISMA was followed for data extraction. RoB 2 and SYRCLE were utilized to assess the risk of bias for in vitro and animal studies. Meta-analysis was performed for in vitro and in vivo articles that investigated THY as an anti-inflammatory agent. Thirty-six and 15 articles were included in the qualitative analysis and meta-analysis, respectively. Studies showed high risk of bias related to sampling, allocation procedures, randomization, and blinding. Even so, for in vitro studies, significant result was observed for IL-2. For in vivo studies, significant results were found for IL-1, IL-17, TNF-α, AST, MPO, and CRP, with higher levels noticed in control groups. THY presents significant properties as anti-inflammatory, ameliorating affections of the digestive system, cardiovascular problems, respiratory system and dermal damages, and burns. Researches are needed to clarify THY dose-response relationship and its mechanism of action, especially in the application of THY as a healing agent.
百里香酚（THY）具有抗菌和抗氧化特性。最近的研究还表明，THY 具有抗炎和愈合特性。本综述重点介绍了有关 THY 作为抗炎和/或伤口愈合剂的体外和体内研究。检索了 PubMed、WebOfScience 和 Scopus。独立审查员进行了所有图表步骤。遵循 PRISMA 进行数据提取。使用 RoB 2 和 SYRCLE 评估体外和动物研究的偏倚风险。对研究 THY 作为抗炎剂的体外和体内文章进行了荟萃分析。定性分析和荟萃分析分别纳入了 36 篇和 15 篇文章。研究表明，与采样、分配程序、随机化和盲法相关的偏倚风险较高。尽管如此，对于体外研究，IL-2 的结果具有显著意义。对于体内研究，IL-1、IL-17、TNF-α、AST、MPO 和 CRP 的结果具有显著意义，对照组的水平较高。THY 具有显著的抗炎特性，可改善消化系统、心血管问题、呼吸系统和皮肤损伤以及烧伤的影响。需要进一步研究以阐明 THY 的剂量反应关系及其作用机制，特别是在将 THY 用作治疗剂方面。
