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人类诺如病毒特异性抗体在生命第一年的广度和动态变化。

Breadth and Dynamics of Human Norovirus-Specific Antibodies in the First Year of Life.

机构信息

Department of Family Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

Takeda Vaccines, Inc., Cambridge, Massachusetts, USA.

出版信息

J Pediatric Infect Dis Soc. 2022 Oct 25;11(10):463-466. doi: 10.1093/jpids/piac067.

DOI:10.1093/jpids/piac067
PMID:35849145
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9595050/
Abstract

We measured antibody binding to diverse norovirus virus-like particles over 12 months in 16 children. All had maternal antibodies at 2 months, with estimated lowest levels at 5 months of age. Antibody increases after 3 months suggested natural infections. This information could guide the timing of future norovirus vaccines.

摘要

我们在 16 名儿童中测量了 12 个月内针对多种诺如病毒样颗粒的抗体结合情况。所有儿童在 2 个月时均具有母体抗体，估计在 5 个月大时抗体水平最低。3 个月后抗体增加表明发生了自然感染。这些信息可以指导未来诺如病毒疫苗的接种时间。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5bf/9595050/366d9908edd0/piac067_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5bf/9595050/366d9908edd0/piac067_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5bf/9595050/366d9908edd0/piac067_fig1.jpg

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2
Application of a multiplex salivary immunoassay to detect sporadic incident norovirus infections.应用多重唾液免疫分析法检测散发诺如病毒感染。
Sci Rep. 2019 Dec 20;9(1):19576. doi: 10.1038/s41598-019-56040-7.
3
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Clin Microbiol Infect. 2023 Apr;29(4):540.e9-540.e15. doi: 10.1016/j.cmi.2022.11.013. Epub 2022 Nov 21.
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