Engineering Research Center of Special Engineering Plastics, Ministry of Education, College of Chemistry, Jilin University, Changchun, 130021, China.
Department of Prosthetic Dentistry, Hospital of Stomatology, Jilin University, Changchun, 130021, China.
Macromol Biosci. 2022 Oct;22(10):e2200114. doi: 10.1002/mabi.202200114. Epub 2022 Jul 28.
Polyetheretherketone (PEEK) has been widely used in bone repair, but it often fails due to bacterial infection. Herein, a high-strength porous polyetheretherketone scaffold (ps-PK) loaded with antibacterial drug-loaded hydrogel strategy is proposed. The prepared ps-PK possesses high porosity (30.8-64.7%) and the compression modulus is between 0.4 and 0.98 GPa. The interconnected pore-type structure endows it with a drug loading capacity. Poly( -lactic acid-co-glycolic acid)-b-Poly(ethylene glycol)-b-Poly( -lactic acid-co-glycolic acid) (PLGA-PEG-PLGA) thermoresponsive hydrogels loaded with vancomycin are used as the drug sustained-release system. The vancomycin-loaded hydrogels in the solution state at a low temperature are filled into a porous polyetheretherketone scaffold (ps-PK-VGel) and formed a gel state after implantation in vivo. The antibacterial rate of ps-PK-VGel against methicillin-resistant staphylococcus aureus in vitro is 99.7% and histological observation in vivo demonstrates that the ps-PK-VGel shows obvious antibacterial activity. Given its excellent antibacterial ability and mechanical properties, the porous PEEK scaffold composite drug-loaded thermosensitive hydrogel has great potential in bone repair surgery applications.
聚醚醚酮（PEEK）已广泛用于骨修复，但常因细菌感染而失效。在此，提出了一种载抗菌药物水凝胶策略的高强度多孔聚醚醚酮支架（ps-PK）。所制备的 ps-PK 具有高孔隙率（30.8-64.7%），压缩模量在 0.4-0.98 GPa 之间。互连成孔型结构赋予其药物负载能力。载万古霉素的聚（-乳酸-co- 乙醇酸）-b-聚（乙二醇）-b-聚（-乳酸-co- 乙醇酸）（PLGA-PEG-PLGA）温敏水凝胶用作药物缓释系统。低温下处于溶液状态的载万古霉素水凝胶填充到多孔聚醚醚酮支架（ps-PK-VGel）中，并在体内植入后形成凝胶状态。体外对耐甲氧西林金黄色葡萄球菌的 ps-PK-VGel 抗菌率为 99.7%，体内组织学观察表明 ps-PK-VGel 具有明显的抗菌活性。鉴于其优异的抗菌能力和机械性能，多孔 PEEK 支架复合载药温敏水凝胶在骨修复手术应用中具有巨大潜力。
