Department of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Dhaka, Bangladesh.
Department of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Dhaka, Bangladesh.
Cytokine. 2022 Sep;157:155962. doi: 10.1016/j.cyto.2022.155962. Epub 2022 Jul 16.
Considerable evidence supports that cytokines are important mediators of pathophysiologic processes within the central nervous system (CNS). Numerous studies have documented the increased production of various cytokines in the human CNS in various neurological and neuropsychiatric disorders. Deciphering cytokine actions in the intact CNS has important implications for our understanding of the pathogenesis and treatment of these disorders. The purpose of this study is to discuss the recent research on treating cytokine storm and amyloids, including stroke, Parkinson's disease (PD), Alzheimer's disease (AD), Huntington's condition, Multi-sclerosis (MS), Amyotrophic Lateral Sclerosis (ALS). Neuroinflammation observed in neurological disorders has a pivotal role in exacerbating Aβ burden and tau hyperphosphorylation, suggesting that stimulating cytokines in response to an undesirable external response could be a checkpoint for treating neurological disorders. Furthermore, the pro-inflammatory cytokines help our immune system through a neuroprotective mechanism in clearing viral infection by recruiting mononuclear cells. This study reveals that cytokine applications may play a vital role in providing novel regulation and methods for the therapeutic approach to neurological disorders and the causes of the deregulation, which is responsible for neuroinflammation and viral infection. However, it needs to be further investigated to clarify better the mechanisms of cytokine release in response to various stimuli, which could be the central point for treating neurological disorders.
大量证据表明细胞因子是中枢神经系统（CNS）病理生理过程中的重要介质。许多研究已经记录了在各种神经和神经精神疾病中，人类中枢神经系统中各种细胞因子的产生增加。破译完整中枢神经系统中的细胞因子作用对我们理解这些疾病的发病机制和治疗具有重要意义。本研究旨在讨论最近关于治疗细胞因子风暴和淀粉样蛋白的研究，包括中风、帕金森病（PD）、阿尔茨海默病（AD）、亨廷顿病、多发性硬化症（MS）、肌萎缩侧索硬化症（ALS）。神经炎症在神经疾病中的观察在加剧 Aβ 负担和 tau 过度磷酸化方面起着关键作用，这表明刺激细胞因子以应对不良的外部反应可能是治疗神经疾病的一个检查点。此外，促炎细胞因子通过招募单核细胞来清除病毒感染，通过神经保护机制帮助我们的免疫系统。本研究揭示了细胞因子的应用可能在为神经疾病的治疗方法和失调的原因提供新的调节和方法方面发挥重要作用，失调是导致神经炎症和病毒感染的原因。然而，需要进一步研究以更好地阐明对各种刺激反应的细胞因子释放的机制，这可能是治疗神经疾病的关键点。
