Rack P M, Fox J E
J Neurol Neurosurg Psychiatry. 1987 Apr;50(4):460-4. doi: 10.1136/jnnp.50.4.460.
The abductor digiti minimi of a patient had undergone partial denervation with some subsequent re-innervation. Cooling of the muscle caused a severe reduction in the EMG and force which accompanied either voluntary effort or tetanic nerve stimulation, but it had little effect on the response to single stimuli. The ineffectual attempts at voluntary contraction of the cooled muscle did, however, block the response to single nerve stimuli. Administration of cholinesterase inhibitors did not improve neuromuscular transmission in the cooled muscle, but usually made it worse. It is concluded that depolarisation block may contribute to the weakness of cooled denervated muscles.
一名患者的小指展肌曾经历部分去神经支配，随后有一些再支配。肌肉冷却导致肌电图和力量严重降低，这在自主用力或强直神经刺激时都会出现，但对单刺激反应影响很小。然而，冷却肌肉自主收缩的无效尝试确实会阻断对单神经刺激的反应。给予胆碱酯酶抑制剂并不能改善冷却肌肉中的神经肌肉传递，反而通常会使其恶化。结论是去极化阻滞可能导致冷却的失神经肌肉无力。
