SRM Institute of Science and Technology, SRM nagar, College of Engineering and Technology, Kattankulathur, Department of Genetic Engineering, 603203, Kanchipuram, Chennai, India.
SRM Institute of Science and Technology, SRM nagar, College of Engineering and Technology, Kattankulathur, Department of Genetic Engineering, 603203, Kanchipuram, Chennai, India.
Bull Cancer. 2022 Sep;109(9):960-971. doi: 10.1016/j.bulcan.2022.05.007. Epub 2022 Jul 17.
Triple-negative breast cancer (TNBC) is one of the most fatal and aggressive type of cancer in younger population. TNBC is poorly diagnosed, detected only at later stages with low survival rate and high chemoresistance. The expression of the cancer stem cell (CSC) markers has critical role in chemoresistance and recurrence. In this review, focus is on potential CSC targets and treatment strategies for TNBC. Inhibition of proliferative genes involved in TNBC can reduce its spread and tumor invasiveness. Also, inhibiting proteins that are involved in signaling pathways that help in the expression of CSC markers can improve chemosensitivity. Thus, combining inhibition of critical genes and proteins can be a potential therapy strategy. Therefore, functioning of γ-secretase inhibitors (GSI-IX, Presenilin1/2, Pen-2, Nicastrin, APH-1), BEZ235, GANT61 inhibitor, NVP-LDE225, GSK3β inhibitor, AMPK activator (Aza- podophyllotoxin, demethoxycurcumin, N, N-diarylurea FND-4b) and MYC inhibitors (Triptolide, Quinoxalines) in TNBC are reviewed extensively.
三阴性乳腺癌（TNBC）是年轻人群中最致命和侵袭性最强的癌症之一。TNBC 诊断困难，仅在晚期发现，生存率低，化疗耐药性高。癌症干细胞（CSC）标志物的表达在化疗耐药性和复发中起着关键作用。在这篇综述中，重点关注 TNBC 的潜在 CSC 靶点和治疗策略。抑制参与 TNBC 的增殖基因可以减少其扩散和肿瘤侵袭性。此外，抑制参与信号通路的蛋白，这些蛋白有助于 CSC 标志物的表达，可以提高化疗敏感性。因此，抑制关键基因和蛋白的功能可能是一种潜在的治疗策略。因此，广泛综述了 γ-分泌酶抑制剂（GSI-IX、早老素 1/2、Pen-2、Nicastrin、APH-1）、BEZ235、GANT61 抑制剂、NVP-LDE225、GSK3β 抑制剂、AMPK 激活剂（Aza-鬼臼毒素、脱甲氧基姜黄素、N，N-二芳基脲 FND-4b）和 MYC 抑制剂（雷公藤内酯、喹喔啉）在 TNBC 中的作用。
