Yu Chao-Chao, Du Yan-Jun, Li Jin, Li Yi, Wang Li, Kong Li-Hong, Zhang Ying-Wen
1Department of Integrated Chinese and Western Medicine, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, Hubei, China.
2College of Acupuncture and Orthopedics, Hubei University of Chinese Medicine, Wuhan, Hubei, China.
Aging Dis. 2022 Jul 11;13(4):1092-1105. doi: 10.14336/AD.2021.1205.
Due to global population aging and modern lifestyle changes, the incidence of central nervous system (CNS) disorders, such as neurodegenerative diseases, neuropsychiatric disorders, and cerebrovascular diseases, is increasing and has become a major public health challenge. Current medications commonly used in the clinic are far from satisfactory and may cause serious side effects. Therefore, the identification of novel drugs for the effective management of CNS diseases is very urgent. Puerarin, a highly bioactive ingredient isolated from , is known to possess a broad spectrum of pharmacological properties including anti-diabetic, anti-inflammatory, anti-antioxidant, neuroprotective, and cardioprotective features. However, its clinical application is limited due to its poor water solubility. Since puerarin has demonstrated a wide range of neuroprotective functions in various CNS diseases, such as Alzheimer's disease, Parkinson's disease, cerebral ischemia, depression, and spinal cord injury, it has been attracting increasingly intense attention worldwide. In this review, we intend to extensively summarize the research progress on neuroprotective mechanisms of puerarin in recent years and discuss the future directions of its application in CNS disease treatment.
由于全球人口老龄化和现代生活方式的改变，中枢神经系统（CNS）疾病的发病率正在上升，已成为一项重大的公共卫生挑战，这些疾病包括神经退行性疾病、神经精神疾病和脑血管疾病。目前临床上常用的药物远不能令人满意，并且可能会引起严重的副作用。因此，识别用于有效治疗中枢神经系统疾病的新型药物迫在眉睫。葛根素是从[具体来源未给出]中分离出的一种具有高生物活性的成分，已知具有广泛的药理特性，包括抗糖尿病、抗炎、抗氧化、神经保护和心脏保护作用。然而，由于其水溶性差，其临床应用受到限制。由于葛根素在各种中枢神经系统疾病（如阿尔茨海默病、帕金森病、脑缺血、抑郁症和脊髓损伤）中已显示出广泛的神经保护功能，它在全球范围内受到越来越多的关注。在这篇综述中，我们打算广泛总结近年来葛根素神经保护机制的研究进展，并讨论其在中枢神经系统疾病治疗中的应用前景。
