加西考瓦酮C-E，从Choisy的Roxb.根中分离得到的三种新的水合香叶基取代氧杂蒽酮及其对β-葡萄糖苷酶的抑制活性。
Garcicowanones C-E, three new hydrated-geranylated xanthones from the roots of Roxb. ex Choisy, and their -glucosidase inhibition activities.
作者信息
An Nguyen Thi Kim, Van Hien Nguyen, Thi Thuy Nguyen, Lan Phuong Doan, Gia Bach Ha, Tra Nguyen Thanh, Quang Tung Nguyen, Tham Pham Thi, Tai Bui Huu, Thu Thuy Tran Thi
机构信息
Hanoi University of Industry, Bac Tu Liem, Hanoi, Vietnam.
Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology (VAST), Vietnam.
出版信息
Nat Prod Res. 2023 Oct-Nov;37(21):3668-3676. doi: 10.1080/14786419.2022.2098956. Epub 2022 Jul 20.
Three new xanthones, garcicowanones C-E (), and six known xanthones () were isolated from the roots of Roxb. ex Choisy. Their chemical structures were determined using spectroscopic technics, including HR-ESI-MS and 2 D NMR. All isolated compounds were evaluated for α-glucosidase inhibition. Cowanol ( and norcowanin ( had the most potent -glucosidase inhibitory activity, with respective IC values of 33.5 ± 0.8 and 17.2 ± 0.3 µM, compared with the positive control, acarbose (IC 257.3 ± 4.8 µM).
从山竹子（Garcinia cowa Roxb. ex Choisy）的根部分离出了三种新的呫吨酮，即藤黄考瓦酮C - E（），以及六种已知的呫吨酮（）。使用包括高分辨电喷雾电离质谱（HR - ESI - MS）和二维核磁共振（2D NMR）在内的光谱技术确定了它们的化学结构。对所有分离出的化合物进行了α - 葡萄糖苷酶抑制活性评估。柯诺醇（）和降柯诺宁（）具有最强的α - 葡萄糖苷酶抑制活性，与阳性对照阿卡波糖（IC50为257.3 ± 4.8 μM）相比，其IC50值分别为33.5 ± 0.8和17.2 ± 0.3 μM。
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