遗传和环境变异影响多基因风险评分的可转移性。
Genetic and environmental variation impact transferability of polygenic risk scores.
机构信息
Program in Bioinformatics, Loyola University Chicago, Chicago, IL 60660, USA.
Program in Bioinformatics, Loyola University Chicago, Chicago, IL 60660, USA; Department of Biology, Loyola University Chicago, Chicago, IL 60660, USA.
出版信息
Cell Rep Med. 2022 Jul 19;3(7):100687. doi: 10.1016/j.xcrm.2022.100687.
Abstract
Even when polygenic risk scores (PRSs) are trained in African ancestral populations, Kamiza and colleagues showed that genetic and environmental variation within sub-Saharan African populations impacts prediction performance, highlighting the challenges of clinical implementation of PRSs for risk assessment.
摘要
即使多基因风险评分 (PRSs) 是在非洲祖先群体中进行训练的，Kamiza 及其同事也表明，撒哈拉以南非洲人群内的遗传和环境变异会影响预测性能，突出了 PRSs 在风险评估中的临床实施所面临的挑战。
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