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巴基斯坦的耐多药结核病:挑战、努力及建议

MDR-TB in Pakistan: Challenges, efforts, and recommendations.

作者信息

Khan Mahad Ahmed, Bilal Wajeeha, Asim Hanzla, Rahmat Zainab Syyeda, Essar Mohammad Yasir, Ahmad Shoaib

机构信息

Dow University of Health Sciences, Pakistan.

Kabul University of Medical Sciences, Kabul, Afghanistan.

出版信息

Ann Med Surg (Lond). 2022 Jun 17;79:104009. doi: 10.1016/j.amsu.2022.104009. eCollection 2022 Jul.

DOI:10.1016/j.amsu.2022.104009
PMID:35860138
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9289334/
Abstract

Tuberculosis (TB), a global health concern is also a leading cause of mortality and morbidity across Pakistan affecting a major proportion of the population. The absence of an integrated system to control the spread of TB has led to a rise in multidrug resistant strains of TB (MDR-Tb) which do not exhibit any sensitivity towards the first line therapy for TB. Such adverse circumstances call for effective planning strategies to mitigate the health hazards of MDR-TB. This article briefly highlights the challenges encountered by the already burdened healthcare system and suggests relatively inexpensive approaches to tackle the ongoing crisis associated with MDR-TB on a national scale.

摘要

结核病是一个全球卫生问题,也是巴基斯坦各地死亡率和发病率的主要原因,影响着很大一部分人口。缺乏控制结核病传播的综合系统导致耐多药结核病(MDR-Tb)菌株增加,这些菌株对结核病一线治疗没有任何敏感性。这种不利情况需要有效的规划策略来减轻耐多药结核病的健康危害。本文简要强调了本已不堪重负的医疗系统所面临的挑战,并提出了相对低成本的方法来应对全国范围内与耐多药结核病相关的持续危机。

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Early detection of MDR Mycobacterium tuberculosis mutations in Pakistan.巴基斯坦耐多药结核分枝杆菌突变的早期检测。
Sci Rep. 2021 Aug 18;11(1):16736. doi: 10.1038/s41598-021-96116-x.
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