Zhang Jinshi, Wang Binqi, Yuan Shizhu, He Qiang, Jin Juan
Urology & Nephrology Center, Department of Nephrology, Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College), Hangzhou, China.
Zhejiang Chinese Medical University, The Second School of Clinical Medical, Hangzhou, China.
Front Mol Biosci. 2022 Jun 30;9:951275. doi: 10.3389/fmolb.2022.951275. eCollection 2022.
Ferroptosis is a novel cell death method discovered in recent years. It is usually accompanied by massive accumulations of iron and lipid peroxidation during cell death. Recent studies have shown that ferroptosis is closely associated with the pathophysiological processes of many diseases, such as tumors, neurological diseases, localized ischemia-reperfusion injury, kidney injury, and hematological diseases. How to intervene in the incidence and development of associated diseases by regulating the ferroptosis of cells has become a hot topic of research. This article provides a review of the role of ferroptosis in the pathogenesis and potential treatment of acute kidney injury.
铁死亡是近年来发现的一种新型细胞死亡方式。它通常在细胞死亡过程中伴随着铁的大量积累和脂质过氧化。最近的研究表明，铁死亡与许多疾病的病理生理过程密切相关，如肿瘤、神经疾病、局部缺血再灌注损伤、肾损伤和血液系统疾病。如何通过调节细胞铁死亡来干预相关疾病的发生和发展已成为研究的热点。本文综述了铁死亡在急性肾损伤发病机制及潜在治疗中的作用。
