Huzhou Center for Disease Control and Prevention, Huzhou, Zhejiang, China.
Lett Appl Microbiol. 2022 Nov;75(5):1225-1231. doi: 10.1111/lam.13790. Epub 2022 Aug 5.
Human adenoviruses (HAdVs) are prevalent worldwide and are a common cause of respiratory tract infection in people of all ages. However, little is known about HAdV infection among children with severe acute respiratory infection (SARI). The present study retrospectively analysed the molecular typing and epidemiological characteristics of HAdV-positive samples from children with SARI from January 2017 to December 2021 in Huzhou. The results showed that 89 (8·27%) of 1078 SARI paediatric patients were positive for HAdVs. Children <5 years of age accounted for 87·64% of the positive cases. The peak seasons for HAdV infection were the first quarter and the fourth quarter. In addition, HAdV-B and HAdV-C were circulating among paediatric patients with SARI, of which the B3 genotype (n = 30, 51·72%) was the most prevalent and was detected every year, indicating that B3 is the main epidemic strain in the Huzhou area, followed by C1 (n = 9, 15·52%), C2 (n = 7, 12·07%) and B7 (n = 5, 8·62%). These findings provide a benchmark for future epidemiology and prevention strategies for HAdVs.
人腺病毒（HAdV）在全球广泛流行，是各年龄段人群呼吸道感染的常见病因。然而，人们对重症急性呼吸道感染（SARI）患儿的 HAdV 感染知之甚少。本研究回顾性分析了 2017 年 1 月至 2021 年 12 月期间湖州 SARI 患儿 HAdV 阳性样本的分子分型和流行病学特征。结果显示，在 1078 例 SARI 患儿中，89 例（8.27%）HAdV 阳性。阳性病例中年龄<5 岁者占 87.64%。HAdV 感染的高发季节为第一季度和第四季度。此外，HAdV-B 和 HAdV-C 在 SARI 患儿中流行，其中 B3 基因型（n=30，51.72%）最为流行，每年均有检出，表明 B3 是湖州地区的主要流行株，其次是 C1（n=9，15.52%）、C2（n=7，12.07%）和 B7（n=5，8.62%）。这些发现为未来 HAdV 的流行病学和预防策略提供了依据。
