Iizumi T, Yazaki T, Kanoh S, Kondo I, Koiso K
J Urol. 1987 Jun;137(6):1304-6. doi: 10.1016/s0022-5347(17)44488-0.
A new epithelial cell line, TSU-Pr1, from a human prostatic adenocarcinoma metastatic to lymph node has been established in long term tissue culture. The cultured cells show loss of contact inhibition, rapid growth in vitro and growth in athymic nude mice. Karyotypic analysis demonstrated an aneuploid karyotype with a modal chromosome number of 80 including a Y-chromosome and at least 10 marker chromosomes. The cells produced only a small amount of prostatic acid phosphatase, and heterotransplanted tumors did not have nuclear androgen receptors.
已通过长期组织培养建立了一种新的上皮细胞系TSU-Pr1，该细胞系源自转移至淋巴结的人前列腺腺癌。培养的细胞表现出接触抑制丧失、体外快速生长以及在无胸腺裸鼠体内生长的特性。核型分析显示为非整倍体核型，众数染色体数为80条，包括一条Y染色体和至少10条标记染色体。这些细胞仅产生少量前列腺酸性磷酸酶，异种移植肿瘤没有核雄激素受体。
