National Centre of Excellence in Analytical Chemistry, University of Sindh Jamshoro, Sindh, 76080, Pakistan.
National Centre of Excellence in Analytical Chemistry, University of Sindh Jamshoro, Sindh, 76080, Pakistan.
J Trace Elem Med Biol. 2022 Sep;73:127038. doi: 10.1016/j.jtemb.2022.127038. Epub 2022 Jul 16.
Coronavirus disease 2019 (COVID-19) is a systemic disease affecting multiple organs. Furthermore, viral infection depletes several trace elements and promotes complex biochemical reactions in the body. Smoking has been linked to the incidence of COVID-19 and associated mortality, and it may impact clinical effects, viral and bacterial conversion, and treatment outcomes.
To study the relationship between severe acute respiratory syndrome coronavirus type 2 and the elemental concentrations of selenium (Se) and mercury (Hg) in biological samples from smokers and nonsmokers infected with the virus and in healthy individuals.
We evaluated changes in the concentrations of essential (Se) and toxic (Hg) elements in biological samples (blood, nasal fluid, saliva, sputum, serum, and scalp hair) collected from male smokers and nonsmokers (aged 29-59 years) infected with COVID-19 and from healthy men in the same age group. The patients lived in different cities in Sindh Province, Pakistan. The Se and Hg concentrations were determined using atomic absorption spectrophotometry.
Se concentrations in all types of biological samples from smokers and nonsmokers with COVID-19 were lower than those of healthy smokers and nonsmokers. Hg concentrations were elevated in both smokers and nonsmokers with COVID-19.
In the current study, persons infected with COVID-19 had higher concentrations of toxic Hg, which could cause physiological disorders, and low concentrations of essential Se, which can also cause weakness. COVID-19 infection showed positive correlations with levels of mercury and selenium. Thus, additional clinical and experimental investigations are essential.
2019 年冠状病毒病（COVID-19）是一种影响多个器官的全身性疾病。此外，病毒感染会消耗多种痕量元素，并促进体内复杂的生化反应。吸烟与 COVID-19 的发病率和相关死亡率有关，它可能会影响临床效果、病毒和细菌转化以及治疗结果。
研究严重急性呼吸综合征冠状病毒 2 型与吸烟者和非吸烟者感染病毒以及健康个体生物样本中硒（Se）和汞（Hg）元素浓度之间的关系。
我们评估了来自 COVID-19 感染的男性吸烟者和非吸烟者（年龄 29-59 岁）以及同年龄组健康男性的血液、鼻液、唾液、痰、血清和头皮头发等生物样本中必需（Se）和有毒（Hg）元素浓度的变化。患者居住在巴基斯坦信德省的不同城市。使用原子吸收分光光度法测定 Se 和 Hg 浓度。
COVID-19 吸烟者和非吸烟者的所有类型生物样本中的 Se 浓度均低于健康吸烟者和非吸烟者。COVID-19 患者的吸烟者和非吸烟者的 Hg 浓度均升高。
在目前的研究中，感染 COVID-19 的人血液中有毒 Hg 的浓度较高，这可能导致生理紊乱，而必需的 Se 浓度较低，这也可能导致虚弱。COVID-19 感染与汞和硒水平呈正相关。因此，需要进行更多的临床和实验研究。
