Lee S L, Lam T H, Leung T H, Wong W H S, Schooling M, Leung G M, Lau Y L
Department of Paediatrics & Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong.
ScientificWorldJournal. 2012;2012:542983. doi: 10.1100/2012/542983. Epub 2012 Aug 13.
We examined the hypothesis that foetal exposure to maternal passive smoking is associated with childhood asthma, allergic rhinitis, and eczema. METHODS. The study was a population-based cross-sectional survey of Hong Kong Chinese children aged ≤14 years carried out in 2005 to 2006. RESULTS. Foetal exposure to maternal passive smoking was significantly associated with wheeze ever (OR 2.05; 95% CI 1.58-2.67), current wheeze (OR 2.06; 95% CI 1.48-2.86), allergic rhinitis ever (OR 1.22; 95% CI 1.09-1.37), and eczema ever (OR 1.61; 95% CI 1.38-1.87). Foetal exposure to maternal active smoking was significantly associated with asthma ever (OR 2.10; 95% CI 1.14-3.84), wheeze ever (OR 2.46; 95% CI 1.27-4.78), and current wheeze (OR 2.74; 95% CI 1.24-6.01) but not with allergic rhinitis ever (OR 1.01; 95% CI 0.70-1.46) or eczema ever (OR 1.38; 95% CI 0.87-2.18). The dose response relationship between wheeze ever and current wheeze with increasing exposure, from no exposure to maternal passive smoking and then to maternal active smoking, further supports causality. CONCLUSION. There is significant association between foetal exposure to maternal passive smoking and maternal active smoking with childhood asthma and related atopic illnesses. Further studies are warranted to explore the potential causal relationship.
我们检验了胎儿暴露于母亲被动吸烟与儿童哮喘、过敏性鼻炎和湿疹相关的假设。方法。该研究是2005年至2006年对香港年龄≤14岁的中国儿童进行的基于人群的横断面调查。结果。胎儿暴露于母亲被动吸烟与曾经喘息（比值比2.05；95%可信区间1.58 - 2.67）、当前喘息（比值比2.06；95%可信区间1.48 - 2.86）、曾经过敏性鼻炎（比值比1.22；95%可信区间1.09 - 1.37）和曾经湿疹（比值比1.61；95%可信区间1.38 - 1.87）显著相关。胎儿暴露于母亲主动吸烟与曾经哮喘（比值比2.10；95%可信区间1.14 - 3.84）、曾经喘息（比值比2.46；95%可信区间1.27 - 4.78）和当前喘息（比值比2.74；95%可信区间1.24 - 6.01）显著相关，但与曾经过敏性鼻炎（比值比1.01；95%可信区间0.70 - 1.46）或曾经湿疹（比值比1.38；95%可信区间0.87 - 2.18）无关。曾经喘息和当前喘息与暴露增加（从无母亲被动吸烟暴露到母亲主动吸烟暴露）之间的剂量反应关系进一步支持了因果关系。结论。胎儿暴露于母亲被动吸烟和母亲主动吸烟与儿童哮喘及相关特应性疾病之间存在显著关联。有必要进行进一步研究以探索潜在的因果关系。
