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Undifferentiated Induced Pluripotent Stem Cells as a Genetic Model for Nonalcoholic Fatty Liver Disease.

作者信息

Muñoz Antonio, Theusch Elizabeth, Kuang Yu-Lin, Nalula Gilbert, Peaslee Caitlin, Dorlhiac Gabriel, Landry Markita P, Streets Aaron, Krauss Ronald M, Iribarren Carlos, Mattis Aras N, Medina Marisa W

机构信息

Department of Pediatrics, University of California San Francisco, San Francisco, California.

Department of Pathology, University of California San Francisco, San Francisco, California.

出版信息

Cell Mol Gastroenterol Hepatol. 2022;14(5):1174-1176.e6. doi: 10.1016/j.jcmgh.2022.07.009. Epub 2022 Jul 19.

DOI:10.1016/j.jcmgh.2022.07.009
PMID:35863744
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9608362/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5009/9608362/0a98dc7d94a1/fx2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5009/9608362/cad435284000/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5009/9608362/44e9b31d254a/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5009/9608362/8c8dffdaa829/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5009/9608362/0a98dc7d94a1/fx2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5009/9608362/cad435284000/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5009/9608362/44e9b31d254a/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5009/9608362/8c8dffdaa829/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5009/9608362/0a98dc7d94a1/fx2.jpg

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本文引用的文献

1
Doxycycline Significantly Enhances Induction of Induced Pluripotent Stem Cells to Endoderm by Enhancing Survival Through Protein Kinase B Phosphorylation.强力霉素通过增强蛋白激酶 B 磷酸化来提高细胞存活率，从而显著增强诱导多能干细胞向内胚层的诱导。
Hepatology. 2021 Oct;74(4):2102-2117. doi: 10.1002/hep.31898.
2
Genetic variants modulate gene expression statin response in human lymphoblastoid cell lines.基因变异可调节人类淋巴母细胞系中基因表达对他汀类药物的反应。
BMC Genomics. 2020 Aug 12;21(1):555. doi: 10.1186/s12864-020-06966-4.
3
Evaluation of commonly used ectoderm markers in iPSC trilineage differentiation.
Sex difference in liver diseases: How preclinical models help to dissect the sex-related mechanisms sustaining NAFLD and hepatocellular carcinoma.
肝脏疾病中的性别差异：临床前模型如何有助于剖析维持非酒精性脂肪性肝病和肝细胞癌的性别相关机制。
iScience. 2023 Oct 30;26(12):108363. doi: 10.1016/j.isci.2023.108363. eCollection 2023 Dec 15.
诱导多能干细胞三系分化中常用外胚层标志物的评估
Stem Cell Res. 2019 May;37:101434. doi: 10.1016/j.scr.2019.101434. Epub 2019 Apr 10.
4
Human-based systems: Mechanistic NASH modelling just around the corner?基于人体的系统：机制性非酒精性脂肪性肝炎建模即将出现？
Pharmacol Res. 2018 Aug;134:257-267. doi: 10.1016/j.phrs.2018.06.029. Epub 2018 Jun 30.
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Causal relationship of hepatic fat with liver damage and insulin resistance in nonalcoholic fatty liver.非酒精性脂肪肝中肝脂肪与肝损伤和胰岛素抵抗的因果关系。
J Intern Med. 2018 Apr;283(4):356-370. doi: 10.1111/joim.12719. Epub 2017 Dec 27.
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Pharmacogenomics J. 2017 Jun;17(3):222-229. doi: 10.1038/tpj.2016.12. Epub 2016 Mar 1.
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Biomed Res Int. 2015;2015:460190. doi: 10.1155/2015/460190. Epub 2015 Jul 27.
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Diabetes Metab. 2003 Nov;29(5):478-85. doi: 10.1016/s1262-3636(07)70061-7.