Gao Liang, Huang Weiling, Cai Laisheng, Peng Yufen
Department of Neurology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, People's Republic of China.
J Pain Res. 2022 Mar 10;15:715-722. doi: 10.2147/JPR.S353249. eCollection 2022.
To assess Parkinson's disease (PD)-related pain using the Chinese translation of King's Parkinson's disease Pain Scale (KPPS).
A cohort of 200 patients with primary PD was recruited for this study. Their demographic and clinical features, including age, disease duration, levodopa equivalent daily dose (LEDD), and scores on the Unified Parkinson's Disease Rating Scale-III (UPDRS III), Hoehn-Yahr Scale (H&Y), Mini-Mental State Examination (MMSE), Activities of Daily Living Scale (ADL), Hamilton Depression Rating Scale (HAMD), Hamilton Anxiety Rating Scale (HAMA), Pittsburgh Sleep Quality Index (PSQI), Visual Analogue Scale (VAS) and KPPS, were recorded.
The prevalence of PD-related pain was 44.5%. Among the patients with PD-related pain, the average KPPS score was 41.2 ± 26.8. Pain was most commonly located in the lower limbs (60.7%), upper limbs (22.5%) and waist (21.3%). The most common pain type was musculoskeletal pain (68.5%). Compared with the PD group without pain, the PD group with pain had a longer disease duration ( = 0.022), higher LEDD ( = 0.008), higher UPDRSIII score ( = 0.018), higher H&Y stage ( = 0.003), higher HAMD score ( < 0.001), higher HAMA score ( < 0.001), lower ADL score ( = 0.046) and higher PSQI score ( < 0.001). PD-related pain was correlated with the H&Y stage and the PSQI score ( < 0.05). Cut-off points of 0, 34, and 70 were obtained to discriminate pain severity levels between no pain, mild, moderate, and severe pain, respectively.
Chinese version of KPPS is not only an easy tool for characterization and scoring of pain in PD patients but also has the ability to distinguish between different levels of pain severity.
使用国王帕金森病疼痛量表（KPPS）的中文译本评估帕金森病（PD）相关疼痛。
本研究招募了200例原发性PD患者。记录他们的人口统计学和临床特征，包括年龄、病程、左旋多巴等效日剂量（LEDD）、统一帕金森病评定量表第三部分（UPDRS III）评分、霍恩-亚尔分级量表（H&Y）评分、简易精神状态检查表（MMSE）评分、日常生活活动量表（ADL）评分、汉密尔顿抑郁评定量表（HAMD）评分、汉密尔顿焦虑评定量表（HAMA）评分、匹兹堡睡眠质量指数（PSQI）评分、视觉模拟量表（VAS）评分和KPPS评分。
PD相关疼痛的患病率为44.5%。在有PD相关疼痛的患者中，KPPS平均评分为41.2±26.8。疼痛最常位于下肢（60.7%）、上肢（22.5%）和腰部（21.3%）。最常见的疼痛类型是肌肉骨骼疼痛（68.5%）。与无疼痛的PD组相比，有疼痛的PD组病程更长（P = 0.022）、LEDD更高（P = 0.008）、UPDRSIII评分更高（P = 0.018）、H&Y分期更高（P = 0.003）、HAMD评分更高（P < 0.001）、HAMA评分更高（P < 0.001）、ADL评分更低（P = 0.046）且PSQI评分更高（P < 0.001）。PD相关疼痛与H&Y分期和PSQI评分相关（P < 0.05）。分别获得了0、34和70的截断点，以区分无疼痛、轻度、中度和重度疼痛之间的疼痛严重程度水平。
KPPS中文版不仅是一种用于PD患者疼痛特征描述和评分的简便工具，而且有能力区分不同程度的疼痛严重程度。
