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用于树枝状纳米凝胶疗法的非化学计量硫醇-烯化学

Off-Stoichiometric Thiol-Ene Chemistry to Dendritic Nanogel Therapeutics.

作者信息

Zhang Yuning, Andrén Oliver C J, Nordström Randi, Fan Yanmiao, Malmsten Martin, Mongkhontreerat Surinthra, Malkoch Michael

机构信息

KTH Royal Institute of Technology Department of Fibre and Polymer Technology SE-100 44 Stockholm Sweden.

Department of Pharmacy Uppsala University SE-751 23 Uppsala Sweden.

出版信息

Adv Funct Mater. 2019 May 2;29(18):1806693. doi: 10.1002/adfm.201806693. Epub 2019 Mar 7.

DOI:10.1002/adfm.201806693
PMID:35865651
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9286377/
Abstract

A novel platform of dendritic nanogels is herein presented, capitalizing on the self-assembly of allyl-functional polyesters based on dendritic-linear-dendritic amphiphiles followed by simple cross-linking with complementary monomeric thiols via UV initiated off-stoichiometric thiol-ene chemistry. The facile approach enabled multigram creation of allyl reactive nanogel precursors, in the size range of 190-295 nm, being readily available for further modifications to display a number of core functionalities while maintaining the size distribution and characteristics of the master batch. The nanogels are evaluated as carriers of a spread of chemotherapeutics by customizing the core to accommodate each individual cargo. The resulting nanogels are biocompatible, displaying diffusion controlled release of cargo, maintained therapeutic efficacy, and decreased cargo toxic side effects. Finally, the nanogels are found to successfully deliver pharmaceuticals into a 3D pancreatic spheroids tumor model.

摘要

本文介绍了一种新型树枝状纳米凝胶平台，该平台利用基于树枝状-线性-树枝状两亲物的烯丙基功能化聚酯的自组装，然后通过紫外光引发的非化学计量硫醇-烯化学与互补的单体硫醇进行简单交联。这种简便的方法能够制备出多克量的烯丙基反应性纳米凝胶前体，其尺寸范围为190-295nm，可方便地进行进一步修饰以展现多种核心功能，同时保持母料的尺寸分布和特性。通过定制核心以容纳每种单独的药物，对纳米凝胶作为多种化疗药物载体进行了评估。所得纳米凝胶具有生物相容性，显示出药物的扩散控制释放、维持的治疗效果以及降低的药物毒副作用。最后，发现纳米凝胶能够成功地将药物递送至三维胰腺球体肿瘤模型中。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f55/9286377/81065a216e32/ADFM-29-1806693-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f55/9286377/26601833b9e4/ADFM-29-1806693-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f55/9286377/9945bd5bc1e8/ADFM-29-1806693-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f55/9286377/e425b48410ac/ADFM-29-1806693-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f55/9286377/13c637841a9d/ADFM-29-1806693-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f55/9286377/81065a216e32/ADFM-29-1806693-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f55/9286377/26601833b9e4/ADFM-29-1806693-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f55/9286377/9945bd5bc1e8/ADFM-29-1806693-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f55/9286377/e425b48410ac/ADFM-29-1806693-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f55/9286377/13c637841a9d/ADFM-29-1806693-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f55/9286377/81065a216e32/ADFM-29-1806693-g002.jpg

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