用于牙周组织再生的3D生物打印技术进展

Advances of 3D bioprinting technology for periodontal tissue regeneration.

作者信息

Chen Huanhuan, Wang Yu, Lai Yue, Meng Chenda, Ning Xiner, Xu Tianmin, Song Guangying, Zhang Yunfan, Lin Yifan, Han Bing

机构信息

Department of Orthodontics, School and Hospital of Stomatology, Peking University, Beijing 100081, China.

National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China.

出版信息

iScience. 2025 Apr 25;28(6):112532. doi: 10.1016/j.isci.2025.112532. eCollection 2025 Jun 20.

DOI:10.1016/j.isci.2025.112532

PMID:40487440

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12141959/

Abstract

3D bioprinting technology for periodontal tissue regeneration is an advanced manufacturing technique that utilizes three-dimensional (3D) printing principles to fabricate intricate, viable structures that are specifically devised to meet with the demand for the periodontal regeneration. Personalized tissue substitutes through 3D bioprinting possesses the capability to promote tissue regeneration in tissue-defective regions. However, the current 3D bioprinting for periodontal tissue engineering still is confronted with many huge challenges that include selecting the optimal rheological properties for precise printing, ensuring the biocompatibility, and facilitating the consistent cell incorporation. In this review, we introduced the pathogenesis of periodontitis and the principle and categories of 3D bioprinting technology. We provided a comprehensive overview of the latest advancements in the application of cutting-edge biofabrication technology of 3D bioprinting for the overall periodontal regeneration, aiming to provide valuable insights for the optimization of 3D bioprinting technology and potential directions for future clinical application.

摘要

用于牙周组织再生的3D生物打印技术是一种先进的制造技术，它利用三维（3D）打印原理来制造复杂的、有活力的结构，这些结构是专门为满足牙周再生的需求而设计的。通过3D生物打印制造的个性化组织替代物具有促进组织缺损区域组织再生的能力。然而，目前用于牙周组织工程的3D生物打印仍然面临许多巨大挑战，包括选择用于精确打印的最佳流变学特性、确保生物相容性以及促进细胞的均匀掺入。在这篇综述中，我们介绍了牙周炎的发病机制以及3D生物打印技术的原理和类别。我们全面概述了3D生物打印这一前沿生物制造技术在整体牙周再生应用中的最新进展，旨在为3D生物打印技术的优化提供有价值的见解以及未来临床应用的潜在方向。