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抗心磷脂 IgG 自身抗体与严重 COVID-19 患者的循环细胞外 DNA 相关。

Anti-cardiolipin IgG autoantibodies associate with circulating extracellular DNA in severe COVID-19.

机构信息

Service d'Immunologie, Biogénopôle, Hôpital de la Timone, Assistance Publique-Hôpitaux de Marseille (AP-HM), Marseille, France.

Department of Anesthesiology and Intensive Care, Assistance Publique Hôpitaux de Marseille, Hôpital Nord, Aix-Marseille University, 13015, Marseille, France.

出版信息

Sci Rep. 2022 Jul 22;12(1):12523. doi: 10.1038/s41598-022-15969-y.

DOI:10.1038/s41598-022-15969-y
PMID:35869087
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9305055/
Abstract

Whereas the detection of antiphospholipid autoantibodies (aPL) in COVID-19 is of increasing interest, their role is still unclear. We analyzed a large aPL panel in 157 patients with COVID-19 according to the disease severity. We also investigated a potential association between aPL and extracellular DNA (exDNA, n = 85) or circulating markers of neutrophil extracellular traps (NET) such as citrullinated histones H3 (CitH3, n = 49). A total of 157 sera of patients infected by SARS-CoV-2 were collected. A large aPL panel including lupus anticoagulant, anti-cardiolipin and anti-beta-2 glycoprotein I (IgG, IgM and IgA), anti-phosphatidylethanolamine IgA, anti-prothrombin (IgG and IgM) was retrospectively analyzed according to the disease severity. We found a total aPL prevalence of 54.8% with almost half of the cases having aCL IgG. Within an extended panel of aPL, only aCL IgG were associated with COVID-19 severity. Additionally, severe patients displayed higher CitH3 levels than mild patients. Interestingly, we highlighted a significant association between the levels of aCL IgG and exDNA only in aCL positive patients with severe disease. In conclusion, we showed a significant link between aPL, namely aCL IgG, and circulating exDNA in patients with severe form of COVID-19, that could exacerbate the thrombo-inflammatory state related to disease severity.

摘要

虽然抗磷脂自身抗体（aPL）在 COVID-19 中的检测受到越来越多的关注，但它们的作用仍不清楚。我们根据疾病严重程度分析了 157 例 COVID-19 患者的大型 aPL 谱。我们还研究了 aPL 与细胞外 DNA（exDNA，n=85）或循环中性粒细胞胞外诱捕网（NET）标志物（如瓜氨酸化组蛋白 H3（CitH3，n=49））之间的潜在关联。共收集了 157 例感染 SARS-CoV-2 的患者血清。根据疾病严重程度，回顾性分析了包括狼疮抗凝剂、抗心磷脂和抗β-2 糖蛋白 I（IgG、IgM 和 IgA）、抗磷脂酰乙醇胺 IgA、抗凝血酶原（IgG 和 IgM）在内的大型 aPL 谱。我们发现总 aPL 患病率为 54.8%，其中近一半病例为 aCL IgG。在 aPL 的扩展谱中，只有 aCL IgG 与 COVID-19 的严重程度相关。此外，严重患者的 CitH3 水平高于轻症患者。有趣的是，我们强调了仅在严重疾病的 aCL 阳性患者中，aCL IgG 与循环 exDNA 之间存在显著关联。总之，我们显示了严重 COVID-19 患者中 aPL（即 aCL IgG）与循环 exDNA 之间存在显著关联，这可能会加重与疾病严重程度相关的血栓炎症状态。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84c7/9307786/83a46cc0f4c2/41598_2022_15969_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84c7/9307786/ed014887b770/41598_2022_15969_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84c7/9307786/db8c04d7e667/41598_2022_15969_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84c7/9307786/dbbbc1152ceb/41598_2022_15969_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84c7/9307786/83a46cc0f4c2/41598_2022_15969_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84c7/9307786/ed014887b770/41598_2022_15969_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84c7/9307786/db8c04d7e667/41598_2022_15969_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84c7/9307786/dbbbc1152ceb/41598_2022_15969_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84c7/9307786/83a46cc0f4c2/41598_2022_15969_Fig4_HTML.jpg

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