Johnson G A, Thompson M B, Drayer B P
Magn Reson Med. 1987 Apr;4(4):351-65. doi: 10.1002/mrm.1910040406.
Magnetic resonance imaging techniques have been developed to enable imaging of the live rat brain with thin (1.2-mm) slices and microscopic pixels (115 X 115 microns). Signal-to-noise ratios high enough to realize the microscopic resolution are obtained with rf coils designed for the subject and through the use of three-dimensional Fourier spin warp imaging. The technique yields 16 contiguous slices. Correlation with fixed pathologic specimens enables unequivocal identification of gray and white matter structures in the brain of a live 200-g rat. Structures clearly visible in the MR images include Ammon's horn, the hypothalamus, corpus callosum and substantia nigra, as well as a number of brainstem nuclei.
磁共振成像技术已得到发展，能够对活鼠大脑进行薄切片（1.2毫米）和微观像素（115×115微米）成像。通过为实验对象设计的射频线圈并利用三维傅里叶自旋扭曲成像，可获得足以实现微观分辨率的信噪比。该技术可生成16个连续切片。与固定病理标本的相关性能够明确识别200克活鼠大脑中的灰质和白质结构。在磁共振图像中清晰可见的结构包括海马角、下丘脑、胼胝体和黑质，以及一些脑干核团。
