Chen Jinlin, Huang Jielite, Liu Zhuoran, Xie Yafeng
Department of Clinical Laboratory, The Second Affiliated Hospital of University of South China, Hengyang 421001, China.
Pathog Dis. 2022 Sep 27;80(1). doi: 10.1093/femspd/ftac023.
The outer membrane proteins (OMPs) of Treponema pallidum subsp. pallidum (T. pallidum), the etiological agent of the sexually transmitted disease syphilis, have long been a hot research topic. Despite many hurdles to studying the pathogen, especially the inability to manipulate T. pallidum in vitro genetically, considerable progress has been made in elucidating the structure, pathogenesis and functions of T. pallidum OMPs. In this review, we integrate this information to garner fresh insights into the role of OMPs in the diagnosis, pathogenicity and vaccine development of T. pallidum. Collectively, the essential scientific discussions herein should provide a framework for understanding the current status and prospects of T. pallidum OMPs.
梅毒螺旋体亚种苍白亚种（梅毒螺旋体）是性传播疾病梅毒的病原体，其外膜蛋白（OMPs）长期以来一直是热门研究课题。尽管研究这种病原体存在许多障碍，尤其是无法在体外对梅毒螺旋体进行基因操作，但在阐明梅毒螺旋体OMPs的结构、发病机制和功能方面已经取得了相当大的进展。在这篇综述中，我们整合这些信息，以获得关于OMPs在梅毒螺旋体诊断、致病性和疫苗开发中作用的新见解。总体而言，本文中重要的科学讨论应能为理解梅毒螺旋体OMPs的现状和前景提供一个框架。
