Lombardi G, Cavanna C, Gramegna G, Scevola D, Michelone G
Microbiologica. 1987 Apr;10(2):189-96.
We evaluated the susceptibility of 618 strains of yeasts belonging to the genus Candida, isolated from various biological specimens. Amphotericin B, Nystatin, Fluorocytosine, Clotrimazole, Miconazole, Econazole and Ketoconazole were tested with the Kirby-Bauer method, modified according to Drouhet and Dupont. The polyenes Amphotericin B and Nystatin and the antimetabolyte Fluorocytosine were the most effective drugs, while the imidazole derivatives (Clotrimazole, Miconazole, Econazole and Ketoconazole) generally showed a lower activity. We emphasize the importance of routine evaluation of the susceptibility of isolated yeasts to the main antimycotic drugs.
我们评估了从各种生物标本中分离出的618株念珠菌属酵母的药敏性。采用根据Drouhet和Dupont修改的Kirby-Bauer方法，对两性霉素B、制霉菌素、氟胞嘧啶、克霉唑、咪康唑、益康唑和酮康唑进行了测试。多烯类药物两性霉素B和制霉菌素以及抗代谢物氟胞嘧啶是最有效的药物，而咪唑衍生物（克霉唑、咪康唑、益康唑和酮康唑）通常显示出较低的活性。我们强调对分离出的酵母对主要抗真菌药物的药敏性进行常规评估的重要性。
