Guaschino S, Michelone G, Stola E, Lombardi G, Spinillo A, Viale P
Biol Res Pregnancy Perinatol. 1986;7(1):20-2.
The authors examined 160 non-selected patients between the 28th and 40th weeks of gestational age with mycotic vaginitis. The chemosusceptibility of the isolated yeast to the main antimycotic drugs was evaluated through the Kirby-Bauer method as well as the determination of MIC. The antimycotic drugs tested were Nystatin, Miconazole, Ketoconazole, Clotrimazole, Amphotericin B, Econazole and 5-Fluorocytosine. The obtained data indicate a lacking effectiveness of Clotrimazole in contrast with the high percentage of therapeutical success reported in the literature. Better results were found with Econazole and the other antimycotic drugs tested. Nystatin is the most effective drug "in vitro". The authors furthermore highlight the utility of MIC determination, above all in the cases of recurrent vaginitis and when systemic therapy is undertaken.
作者对160例孕28至40周患有霉菌性阴道炎的未经过挑选的患者进行了研究。通过 Kirby-Bauer 方法以及最小抑菌浓度（MIC）的测定来评估分离出的酵母菌对主要抗真菌药物的化学敏感性。所测试的抗真菌药物有制霉菌素、咪康唑、酮康唑、克霉唑、两性霉素B、益康唑和5-氟胞嘧啶。所得数据表明，与文献中报道的高治疗成功率相比，克霉唑的有效性不足。使用益康唑和其他所测试的抗真菌药物取得了更好的结果。制霉菌素是“体外”最有效的药物。作者还强调了测定MIC的实用性，尤其是在复发性阴道炎病例以及进行全身治疗时。
