信使核糖核酸（mRNA）严重急性呼吸综合征冠状病毒2（SARS-CoV-2）疫苗接种相关心肌炎的诊断——一项系统评价
Diagnostics of messenger ribonucleic acid (mRNA) severe acute respiratory syndrome-corona virus‑2 (SARS-CoV‑2) vaccination-associated myocarditis-A systematic review.
作者信息
Federspiel Jan M, Ramsthaler Frank, Kettner Mattias, Mall Gerhard
机构信息
Institute of Legal Medicine, Saarland University, Campus Homburg, Kirrbergerstraße, Geb. 49.1, 66421 Homburg Saar, Germany.
Institute of Legal Medicine, Goethe University Frankfurt Main, Kennedyallee 104, 60596 Frankfurt Main, Germany.
出版信息
Rechtsmedizin (Berl). 2023;33(2):125-131. doi: 10.1007/s00194-022-00587-9. Epub 2022 Jul 20.
BACKGROUND
During the recent pandemic with the severe acute respiratory syndrome-corona virus‑2 the first messenger ribonucleic acid (mRNA) vaccines were approved. To facilitate mass vaccination, confidence of the general population in these new vaccines is mandatory, which is in turn strongly dependent on the availability of reliable data on complications.
OBJECTIVE
Summary of the current knowledge on mRNA vaccination-associated myocarditis as a potentially fatal side effect.
METHODS
Systematic literature review.
RESULTS
Diagnostic algorithm for the postmortem diagnosis of mRNA vaccination-associated myocarditis.
CONCLUSION
Autopsy series of fatalities following mRNA SARS-CoV‑2 vaccination up to 6 weeks with subsequent sophisticated and interdisciplinary work-up are necessary to complement clinical data on vaccination-associated myocarditis, especially regarding the incidence of fatal courses.
SUPPLEMENTARY INFORMATION
The online version of this article (10.1007/s00194-022-00587-9) includes a PDF file with supplemental clinical features.
背景
在最近由严重急性呼吸综合征冠状病毒2引发的大流行期间，信使核糖核酸（mRNA）疫苗获得批准。为推动大规模疫苗接种，普通民众对这些新疫苗的信心至关重要，而这又极大地依赖于有关并发症的可靠数据的可得性。
目的
总结关于mRNA疫苗接种相关心肌炎这一潜在致命副作用的现有知识。
方法
系统文献综述。
结果
mRNA疫苗接种相关心肌炎的尸检诊断算法。
结论
有必要对接种mRNA SARS-CoV-2疫苗后6周内死亡病例进行尸检系列研究，并随后进行复杂的多学科检查，以补充疫苗接种相关心肌炎的临床数据，特别是关于致命病程的发生率。
补充信息
本文的在线版本（10.1007/s00194-022-00587-9）包含一个带有补充临床特征的PDF文件。
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