Jiang Qirui, Lin Junyu, Li Chunyu, Hou Yanbing, Shang Huifang
Department of Neurology, Laboratory of Neurodegenerative Disorders, West China Hospital, Sichuan University, Chengdu, China.
Front Neurol. 2022 Jul 7;13:891789. doi: 10.3389/fneur.2022.891789. eCollection 2022.
A growing number of voxel-based morphometry (VBM) studies have demonstrated widespread gray matter (GM) abnormalities in myotonic dystrophy type 1 (DM1), but the findings are heterogeneous. This study integrated previous VBM studies to identify consistent GM changes in the brains of patients with DM1.
Systematic retrieval was conducted in Web of Science, Pubmed, and Embase databases to identify VBM studies that met the inclusion requirements. Data were extracted. The Seed-based d Mapping with Permutation of Subject Images (SDM-PSI) software was used for meta-analysis of voxel aspects.
A total of eight VBM studies were included, including 176 patients with DM1 and 198 healthy controls (HCs). GM volume in patients with DM1 was extensively reduced compared with HCs, including bilateral rolandic operculum, bilateral posterior central gyrus, bilateral precentral gyrus, right insula, right heschl gyrus, right superior temporal gyrus, bilateral supplementary motor area, bilateral middle cingulate gyrus/paracingulate gyrus, left paracentral lobule, and bilateral caudate nucleus. Meta-regression analysis found that regional GM abnormalities were associated with disease duration and Rey-Osterrieth Complex Figure (ROCF)-recall scores.
DM1 is not only a disease of muscle injury but also a multisystem disease involving brain motor and neuropsychiatric regions, providing a basis for the pathophysiological mechanism of DM1.
越来越多基于体素的形态计量学（VBM）研究表明，1型强直性肌营养不良（DM1）患者存在广泛的灰质（GM）异常，但研究结果存在异质性。本研究整合了以往的VBM研究，以确定DM1患者大脑中一致的GM变化。
在Web of Science、Pubmed和Embase数据库中进行系统检索，以确定符合纳入要求的VBM研究。提取数据。使用基于种子点的置换主题图像映射（SDM-PSI）软件对体素方面进行荟萃分析。
共纳入8项VBM研究，包括176例DM1患者和198例健康对照（HC）。与HC相比，DM1患者的GM体积广泛减少，包括双侧中央前回盖、双侧中央后回、双侧中央前回、右侧岛叶、右侧颞横回、右侧颞上回、双侧辅助运动区、双侧扣带回中部/扣带旁回、左侧中央旁小叶和双侧尾状核。荟萃回归分析发现，局部GM异常与病程和雷-奥斯特里思复杂图形（ROCF）回忆评分相关。
DM1不仅是一种肌肉损伤疾病，也是一种涉及脑运动和神经精神区域的多系统疾病，为DM1的病理生理机制提供了依据。
