解读肺腺癌中[具体内容未给出]的预后价值及其与免疫浸润的相关性。
Deciphering Prognostic Value of and Its Correlation With Immune Infiltration in Lung Adenocarcinoma.
作者信息
Chen Jianing, Wen Yaokai, Su Hang, Yu Xin, Hong Ruisheng, Chen Chang, Su Chunxia
机构信息
School of Medicine, Tongji University, Shanghai, China.
Department of Medical Oncology, Shanghai Pulmonary Hospital & Thoracic Cancer Institute, School of Medicine, Tongji University, Shanghai, China.
出版信息
Front Oncol. 2022 Jul 8;12:877878. doi: 10.3389/fonc.2022.877878. eCollection 2022.
BACKGROUND
Lung adenocarcinoma (LUAD) is the most common type of lung cancer, accounting for around 40%. Despite achievements in the treatment approach, the prognosis is still dismal, with overall survival of fewer than five years. Thus, novel prognostic biomarkers are needed to predict the clinical outcomes of individual patients better. has a high mutation rate in the LUAD, which encodes a large abundant protein of striated muscle. However, the value of in prognosis and the immune environment are poorly understood.
METHODS
We investigated the clinicopathological characteristics, transcriptional and protein level, prognostic value, biological function, and its relationship with immune infiltration of gene in LUAD patients through bioinformatics analysis.
RESULTS
expression was significantly lower in LUAD than that in normal lung tissue. Lower expression was associated with worse survival. Besides, is highly expressed in alveolar type 2 cells which were surmised as the origin of LUAD.
CONCLUSION
Our findings indicated the potential prognostic value of and its role as a biomarker for determining the immune infiltration levels in patients with LUAD.
背景
肺腺癌（LUAD）是最常见的肺癌类型，约占40%。尽管治疗方法取得了进展，但预后仍然不佳，总生存期少于五年。因此，需要新的预后生物标志物来更好地预测个体患者的临床结局。在肺腺癌中具有高突变率，它编码一种横纹肌中大量存在的蛋白质。然而，其在预后和免疫环境中的价值了解甚少。
方法
我们通过生物信息学分析，研究了肺腺癌患者中该基因的临床病理特征、转录和蛋白水平、预后价值、生物学功能及其与免疫浸润的关系。
结果
肺腺癌中该基因的表达明显低于正常肺组织。较低的该基因表达与较差的生存率相关。此外，该基因在推测为肺腺癌起源的2型肺泡细胞中高表达。
结论
我们的研究结果表明了该基因的潜在预后价值及其作为确定肺腺癌患者免疫浸润水平生物标志物的作用。
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